Cobalt in PDB 9fxj: Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Pbd-150
Enzymatic activity of Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Pbd-150
All present enzymatic activity of Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Pbd-150:
2.3.2.5;
2.3.2.5;
Protein crystallography data
The structure of Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Pbd-150, PDB code: 9fxj
was solved by
G.Tassone,
C.Pozzi,
S.Mangani,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 74.81 / 3.06 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 86.393, 149.627, 96.158, 90, 96.82, 90 |
| R / Rfree (%) | 17.1 / 20.2 |
Cobalt Binding Sites:
The binding sites of Cobalt atom in the Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Pbd-150
(pdb code 9fxj). This binding sites where shown within
5.0 Angstroms radius around Cobalt atom.
In total 3 binding sites of Cobalt where determined in the Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Pbd-150, PDB code: 9fxj:
Jump to Cobalt binding site number: 1; 2; 3;
In total 3 binding sites of Cobalt where determined in the Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Pbd-150, PDB code: 9fxj:
Jump to Cobalt binding site number: 1; 2; 3;
Cobalt binding site 1 out of 3 in 9fxj
Go back to
Cobalt Binding Sites List in 9fxj
Cobalt binding site 1 out
of 3 in the Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Pbd-150
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Cobalt with other atoms in the Co binding
site number 1 of Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Pbd-150 within 5.0Å range:
|
Cobalt binding site 2 out of 3 in 9fxj
Go back to
Cobalt Binding Sites List in 9fxj
Cobalt binding site 2 out
of 3 in the Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Pbd-150
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Cobalt with other atoms in the Co binding
site number 2 of Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Pbd-150 within 5.0Å range:
|
Cobalt binding site 3 out of 3 in 9fxj
Go back to
Cobalt Binding Sites List in 9fxj
Cobalt binding site 3 out
of 3 in the Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Pbd-150
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Cobalt with other atoms in the Co binding
site number 3 of Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Pbd-150 within 5.0Å range:
|
Reference:
G.Tassone,
C.Pozzi,
S.Mangani.
Metal Ion Binding to Human Glutaminyl Cyclase: A Structural Perspective. Int J Mol Sci V. 25 2024.
ISSN: ESSN 1422-0067
PubMed: 39125848
DOI: 10.3390/IJMS25158279
Page generated: Sat Sep 28 19:49:31 2024
ISSN: ESSN 1422-0067
PubMed: 39125848
DOI: 10.3390/IJMS25158279
Last articles
Zn in 9IRQZn in 9IYX
Zn in 9J8P
Zn in 9IUU
Zn in 9GBF
Zn in 9G2V
Zn in 9G2L
Zn in 9G2X
Zn in 9G2Z
Zn in 9G2K
