Cobalt in PDB 1b59: Complex of Human Methionine Aminopeptidase-2 Complexed with Ovalicin

All present enzymatic activity of Complex of Human Methionine Aminopeptidase-2 Complexed with Ovalicin:
3.4.11.18;

The structure of Complex of Human Methionine Aminopeptidase-2 Complexed with Ovalicin, PDB code: 1b59 was solved by S.Liu, J.C.Clardy, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	6.00 / 1.80
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	89.723, 99.108, 101.292, 90.00, 90.00, 90.00
R / Rfree (%)	17.8 / 22.2

The binding sites of Cobalt atom in the Complex of Human Methionine Aminopeptidase-2 Complexed with Ovalicin (pdb code 1b59). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Complex of Human Methionine Aminopeptidase-2 Complexed with Ovalicin, PDB code: 1b59:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Complex of Human Methionine Aminopeptidase-2 Complexed with Ovalicin


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Complex of Human Methionine Aminopeptidase-2 Complexed with Ovalicin within 5.0Å range: probe atom residue distance (Å) B Occ A:Co481 b:49.0 occ:1.00 O A:HOH695 2.3 34.3 1.0 OD2 A:ASP262 2.3 24.3 1.0 OE2 A:GLU364 2.3 26.2 1.0 NE2 A:HIS331 2.4 23.9 1.0 OE2 A:GLU459 2.4 17.6 1.0 CD A:GLU364 3.0 26.0 1.0 CG A:ASP262 3.1 22.3 1.0 CO A:CO482 3.1 55.8 1.0 OE1 A:GLU364 3.1 22.3 1.0 O11 A:OVA480 3.3 20.4 1.0 CD2 A:HIS331 3.3 23.4 1.0 CE1 A:HIS331 3.3 22.1 1.0 CD A:GLU459 3.5 27.2 1.0 OD1 A:ASP262 3.6 22.8 1.0 CB A:ALA362 3.9 19.4 1.0 OE1 A:GLU459 3.9 24.0 1.0 O A:HOH489 4.0 28.2 1.0 CB A:ASP262 4.1 20.4 1.0 CG A:GLU364 4.3 23.7 1.0 ND1 A:HIS331 4.5 22.3 1.0 CG A:HIS331 4.5 23.8 1.0 OD2 A:ASP251 4.6 21.1 1.0 C1 A:OVA480 4.7 19.7 1.0 CG A:GLU459 4.7 20.0 1.0 C2A A:OVA480 4.8 20.6 1.0 CB A:GLU364 4.9 21.9 1.0

Cobalt binding site 2 out of 2 in the Complex of Human Methionine Aminopeptidase-2 Complexed with Ovalicin


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Complex of Human Methionine Aminopeptidase-2 Complexed with Ovalicin within 5.0Å range: probe atom residue distance (Å) B Occ A:Co482 b:55.8 occ:1.00 OD1 A:ASP262 1.7 22.8 1.0 OD1 A:ASP251 2.2 19.9 1.0 OD2 A:ASP251 2.3 21.1 1.0 O A:HOH695 2.3 34.3 1.0 CG A:ASP262 2.5 22.3 1.0 OE1 A:GLU459 2.5 24.0 1.0 CG A:ASP251 2.5 19.4 1.0 OD2 A:ASP262 2.7 24.3 1.0 CO A:CO481 3.1 49.0 1.0 CD A:GLU459 3.2 27.2 1.0 OE2 A:GLU459 3.2 17.6 1.0 O A:HOH489 3.6 28.2 1.0 CB A:ASP262 3.9 20.4 1.0 CZ A:PHE219 4.0 17.9 1.0 OE1 A:GLU364 4.0 22.3 1.0 CB A:ASP251 4.0 15.2 1.0 O A:HOH496 4.1 25.9 1.0 NE2 A:GLN457 4.2 18.9 1.0 CE1 A:PHE219 4.3 14.8 1.0 C A:ASP262 4.5 18.1 1.0 CA A:ASP262 4.5 21.4 1.0 CB A:ALA264 4.6 17.6 1.0 N A:CYS263 4.6 13.6 1.0 O A:HOH578 4.6 30.1 1.0 CG A:GLU459 4.7 20.0 1.0 CD A:GLU364 4.7 26.0 1.0 O11 A:OVA480 4.8 20.4 1.0 OE2 A:GLU364 4.8 26.2 1.0 CA A:ASP251 4.8 15.4 1.0 CE2 A:PHE219 4.9 19.6 1.0 O A:CYS263 5.0 19.1 1.0

S.Liu, J.Widom, C.W.Kemp, C.M.Crews, J.Clardy. Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin. Science V. 282 1324 1998.
ISSN: ISSN 0036-8075
PubMed: 9812898
DOI: 10.1126/SCIENCE.282.5392.1324