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Cobalt in PDB 1b6a: Human Methionine Aminopeptidase 2 Complexed with Tnp-470

Enzymatic activity of Human Methionine Aminopeptidase 2 Complexed with Tnp-470

All present enzymatic activity of Human Methionine Aminopeptidase 2 Complexed with Tnp-470:
3.4.11.18;

Protein crystallography data

The structure of Human Methionine Aminopeptidase 2 Complexed with Tnp-470, PDB code: 1b6a was solved by S.Liu, J.C.Clardy, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 6.00 / 1.60
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 89.558, 99.060, 101.508, 90.00, 90.00, 90.00
R / Rfree (%) 18.7 / 21.6

Other elements in 1b6a:

The structure of Human Methionine Aminopeptidase 2 Complexed with Tnp-470 also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Human Methionine Aminopeptidase 2 Complexed with Tnp-470 (pdb code 1b6a). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Human Methionine Aminopeptidase 2 Complexed with Tnp-470, PDB code: 1b6a:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in 1b6a

Go back to Cobalt Binding Sites List in 1b6a
Cobalt binding site 1 out of 2 in the Human Methionine Aminopeptidase 2 Complexed with Tnp-470


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Human Methionine Aminopeptidase 2 Complexed with Tnp-470 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co481

b:39.5
occ:1.00
OD2 A:ASP262 2.1 24.6 1.0
O A:HOH698 2.3 33.5 1.0
OE2 A:GLU459 2.3 20.2 1.0
OE2 A:GLU364 2.3 26.6 1.0
NE2 A:HIS331 2.3 17.4 1.0
CG A:ASP262 3.0 19.6 1.0
CO A:CO482 3.0 42.1 1.0
CD A:GLU364 3.1 26.6 1.0
CD2 A:HIS331 3.3 17.1 1.0
O11 A:TN4480 3.3 16.5 1.0
CE1 A:HIS331 3.3 15.7 1.0
OE1 A:GLU364 3.4 23.4 1.0
CD A:GLU459 3.4 20.6 1.0
OD1 A:ASP262 3.5 19.0 1.0
OE1 A:GLU459 3.8 20.3 1.0
CB A:ALA362 3.9 12.8 1.0
O A:HOH485 3.9 23.6 1.0
CB A:ASP262 4.0 18.1 1.0
CG A:GLU364 4.4 23.9 1.0
CG A:HIS331 4.4 17.0 1.0
ND1 A:HIS331 4.5 17.5 1.0
C1 A:TN4480 4.6 14.4 1.0
CG A:GLU459 4.6 15.9 1.0
OD2 A:ASP251 4.7 20.2 1.0
C2A A:TN4480 4.7 16.3 1.0
CB A:GLU364 4.9 22.0 1.0

Cobalt binding site 2 out of 2 in 1b6a

Go back to Cobalt Binding Sites List in 1b6a
Cobalt binding site 2 out of 2 in the Human Methionine Aminopeptidase 2 Complexed with Tnp-470


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Human Methionine Aminopeptidase 2 Complexed with Tnp-470 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co482

b:42.1
occ:1.00
OD1 A:ASP262 1.8 19.0 1.0
O A:HOH698 2.1 33.5 1.0
OD2 A:ASP251 2.2 20.2 1.0
OD1 A:ASP251 2.3 18.1 1.0
OE1 A:GLU459 2.5 20.3 1.0
CG A:ASP262 2.5 19.6 1.0
CG A:ASP251 2.6 16.8 1.0
OD2 A:ASP262 2.7 24.6 1.0
CO A:CO481 3.0 39.5 1.0
CD A:GLU459 3.2 20.6 1.0
OE2 A:GLU459 3.2 20.2 1.0
O A:HOH485 3.6 23.6 1.0
CZ A:PHE219 3.9 13.7 1.0
CB A:ASP262 4.0 18.1 1.0
O A:HOH510 4.0 25.3 1.0
CB A:ASP251 4.1 13.3 1.0
OE1 A:GLU364 4.1 23.4 1.0
NE2 A:GLN457 4.2 15.1 1.0
CE1 A:PHE219 4.3 12.8 1.0
O A:HOH653 4.4 34.2 1.0
O11 A:TN4480 4.4 16.5 1.0
CA A:ASP262 4.6 14.2 1.0
C A:ASP262 4.6 13.2 1.0
N A:CYS263 4.6 13.2 1.0
CB A:ALA264 4.6 12.9 1.0
OE2 A:GLU364 4.7 26.6 1.0
CG A:GLU459 4.7 15.9 1.0
CD A:GLU364 4.7 26.6 1.0
CE2 A:PHE219 4.9 14.9 1.0
CA A:ASP251 4.9 12.4 1.0

Reference:

S.Liu, J.Widom, C.W.Kemp, C.M.Crews, J.Clardy. Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin. Science V. 282 1324 1998.
ISSN: ISSN 0036-8075
PubMed: 9812898
DOI: 10.1126/SCIENCE.282.5392.1324
Page generated: Sun Dec 13 10:34:13 2020

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