Cobalt in the structure of Human Methionine Aminopeptidase 2 (pdb 1bn5)

The binding sites of Cobalt atom in the structure of Human Methionine Aminopeptidase 2 (pdb code 1bn5). This binding sites where shown with 5.0 Angstroms radius around Cobalt atom. The 1bn5 structure was solved by S.LIU, J.WIDOM, C.W.KEMP, C.M.CREWS, J.C.CLARDY, with X-Ray Crystallography technique, brief refinement statistics is given in the table below: Resolution (A) 25.0-1.8 Space group C2221 a (A) 90.490 b (A) 99.380 c (A) 101.590 alpha (°) 90.00 beta (°) 90.00 gamma (°) 90.00 Rfactor (%) 18.3 Rfree (%) 22.8 Cobalt Binding Sites: Cobalt binding site 1 out of 2 in 1bn5 Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Cobalt in the PDB 1bn5. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Cobalt atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Phe219, A: Asp251, A: Asp262, A: Cys263, A: Ala264, A: Glu364, A: Gln457, A: Glu459, A: Co480, A: Hoh626, A: Hoh643, A: Hoh666, A: Hoh700, conact list: Atom Atom Distance (A) Co CE2 A:Phe219 4.85 Co CZ A:Phe219 3.98 Co CE1 A:Phe219 4.35 Co CB A:Asp251 4.24 Co OD2 A:Asp251 2.36 Co OD1 A:Asp251 2.39 Co CG A:Asp251 2.74 Co CB A:Asp262 4.18 Co OD2 A:Asp262 2.92 Co C A:Asp262 4.65 Co OD1 A:Asp262 1.98 Co CG A:Asp262 2.75 Co CA A:Asp262 4.66 Co N A:Cys263 4.64 Co CB A:Ala264 4.62 Co OE1 A:Glu364 4.15 Co OE2 A:Glu364 4.51 Co CD A:Glu364 4.68 Co NE2 A:Gln457 4.15 Co OE1 A:Glu459 2.35 Co OE2 A:Glu459 3.24 Co CD A:Glu459 3.13 Co CG A:Glu459 4.59 Co CO A:Co480 3.14 Co O A:Hoh626 4.34 Co O A:Hoh643 3.97 Co O A:Hoh666 4.75 Co O A:Hoh700 4.95 interactive model: Cobalt binding site 2 out of 2 in 1bn5 Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 2 of Cobalt in the PDB 1bn5. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Cobalt atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Asp251, A: Asp262, A: His331, A: Ala362, A: Glu364, A: Glu459, A: Co479, A: Hoh643, A: Hoh666, conact list: Atom Atom Distance (A) Co OD2 A:Asp251 4.96 Co CB A:Asp262 4.25 Co OD2 A:Asp262 2.33 Co OD1 A:Asp262 3.64 Co CG A:Asp262 3.16 Co NE2 A:His331 2.40 Co ND1 A:His331 4.48 Co CD2 A:His331 3.34 Co CE1 A:His331 3.36 Co CG A:His331 4.50 Co CB A:Ala362 3.98 Co OE1 A:Glu364 3.49 Co CB A:Glu364 4.92 Co OE2 A:Glu364 2.20 Co CD A:Glu364 3.12 Co CG A:Glu364 4.33 Co OE1 A:Glu459 3.80 Co OE2 A:Glu459 2.38 Co CD A:Glu459 3.39 Co CG A:Glu459 4.70 Co CO A:Co479 3.14 Co O A:Hoh643 4.23 Co O A:Hoh666 3.15 interactive model: