Cobalt in PDB 1boa: Human Methionine Aminopeptidase 2 Complexed with Angiogenesis Inhibitor Fumagillin

All present enzymatic activity of Human Methionine Aminopeptidase 2 Complexed with Angiogenesis Inhibitor Fumagillin:
3.4.11.18;

The structure of Human Methionine Aminopeptidase 2 Complexed with Angiogenesis Inhibitor Fumagillin, PDB code: 1boa was solved by S.Liu, J.Widom, C.W.Kemp, C.M.Crews, J.C.Clardy, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.00 / 1.80
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	90.700, 99.580, 101.950, 90.00, 90.00, 90.00
R / Rfree (%)	19.3 / 23.2

The binding sites of Cobalt atom in the Human Methionine Aminopeptidase 2 Complexed with Angiogenesis Inhibitor Fumagillin (pdb code 1boa). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Human Methionine Aminopeptidase 2 Complexed with Angiogenesis Inhibitor Fumagillin, PDB code: 1boa:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Human Methionine Aminopeptidase 2 Complexed with Angiogenesis Inhibitor Fumagillin


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Human Methionine Aminopeptidase 2 Complexed with Angiogenesis Inhibitor Fumagillin within 5.0Å range: probe atom residue distance (Å) B Occ A:Co481 b:47.9 occ:1.00 OD2 A:ASP262 2.2 27.8 1.0 OE2 A:GLU364 2.3 28.9 1.0 OE2 A:GLU459 2.3 20.3 1.0 O A:HOH662 2.4 34.5 1.0 NE2 A:HIS331 2.5 18.3 1.0 CO A:CO482 3.0 48.3 1.0 CD A:GLU364 3.0 28.1 1.0 CG A:ASP262 3.1 24.3 1.0 OE1 A:GLU364 3.3 26.8 1.0 O11 A:FUG480 3.3 19.4 1.0 CD A:GLU459 3.3 22.5 1.0 CD2 A:HIS331 3.4 16.1 1.0 CE1 A:HIS331 3.5 18.6 1.0 OD1 A:ASP262 3.6 24.0 1.0 OE1 A:GLU459 3.8 21.1 1.0 CB A:ALA362 3.9 18.1 1.0 O A:HOH528 4.0 30.5 1.0 CB A:ASP262 4.1 20.7 1.0 CG A:GLU364 4.3 26.4 1.0 CG A:HIS331 4.6 17.1 1.0 CG A:GLU459 4.6 18.0 1.0 ND1 A:HIS331 4.6 17.7 1.0 C1 A:FUG480 4.6 19.0 1.0 C2A A:FUG480 4.7 17.7 1.0 OD2 A:ASP251 4.8 23.5 1.0 CB A:GLU364 4.9 23.4 1.0

Cobalt binding site 2 out of 2 in the Human Methionine Aminopeptidase 2 Complexed with Angiogenesis Inhibitor Fumagillin


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Human Methionine Aminopeptidase 2 Complexed with Angiogenesis Inhibitor Fumagillin within 5.0Å range: probe atom residue distance (Å) B Occ A:Co482 b:48.3 occ:1.00 OD1 A:ASP262 1.9 24.0 1.0 O A:HOH662 2.1 34.5 1.0 OD2 A:ASP251 2.3 23.5 1.0 OD1 A:ASP251 2.3 22.6 1.0 OE1 A:GLU459 2.4 21.1 1.0 CG A:ASP262 2.5 24.3 1.0 OD2 A:ASP262 2.6 27.8 1.0 CG A:ASP251 2.7 21.9 1.0 CO A:CO481 3.0 47.9 1.0 CD A:GLU459 3.1 22.5 1.0 OE2 A:GLU459 3.2 20.3 1.0 O A:HOH528 3.7 30.5 1.0 CB A:ASP262 4.0 20.7 1.0 OE1 A:GLU364 4.0 26.8 1.0 CZ A:PHE219 4.1 15.9 1.0 O A:HOH586 4.1 33.1 1.0 CB A:ASP251 4.2 15.3 1.0 NE2 A:GLN457 4.2 15.8 1.0 CE1 A:PHE219 4.4 14.9 1.0 O A:HOH643 4.4 38.0 1.0 O11 A:FUG480 4.5 19.4 1.0 CA A:ASP262 4.6 18.3 1.0 C A:ASP262 4.6 15.3 1.0 OE2 A:GLU364 4.6 28.9 1.0 CG A:GLU459 4.6 18.0 1.0 N A:CYS263 4.6 12.6 1.0 CB A:ALA264 4.7 12.5 1.0 CD A:GLU364 4.7 28.1 1.0 CE2 A:PHE219 5.0 17.1 1.0 CA A:ASP251 5.0 13.1 1.0

S.Liu, J.Widom, C.W.Kemp, C.M.Crews, J.Clardy. Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin. Science V. 282 1324 1998.
ISSN: ISSN 0036-8075
PubMed: 9812898
DOI: 10.1126/SCIENCE.282.5392.1324