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Cobalt in PDB 1kc2: Structure of the Triple (Lys(Beta)D3ALA, Asp(Beta)C8ALA, ASPCD2ALA) Mutant of the Src SH2 Domain Bound to the Pqpyeeipi Peptide

Enzymatic activity of Structure of the Triple (Lys(Beta)D3ALA, Asp(Beta)C8ALA, ASPCD2ALA) Mutant of the Src SH2 Domain Bound to the Pqpyeeipi Peptide

All present enzymatic activity of Structure of the Triple (Lys(Beta)D3ALA, Asp(Beta)C8ALA, ASPCD2ALA) Mutant of the Src SH2 Domain Bound to the Pqpyeeipi Peptide:
2.7.1.112;

Protein crystallography data

The structure of Structure of the Triple (Lys(Beta)D3ALA, Asp(Beta)C8ALA, ASPCD2ALA) Mutant of the Src SH2 Domain Bound to the Pqpyeeipi Peptide, PDB code: 1kc2 was solved by O.Y.Lubman, G.Waksman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.29 / 2.10
Space group I 4 2 2
Cell size a, b, c (Å), α, β, γ (°) 62.447, 62.447, 133.680, 90.00, 90.00, 90.00
R / Rfree (%) 22.9 / 26.7

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Structure of the Triple (Lys(Beta)D3ALA, Asp(Beta)C8ALA, ASPCD2ALA) Mutant of the Src SH2 Domain Bound to the Pqpyeeipi Peptide (pdb code 1kc2). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the Structure of the Triple (Lys(Beta)D3ALA, Asp(Beta)C8ALA, ASPCD2ALA) Mutant of the Src SH2 Domain Bound to the Pqpyeeipi Peptide, PDB code: 1kc2:

Cobalt binding site 1 out of 1 in 1kc2

Go back to Cobalt Binding Sites List in 1kc2
Cobalt binding site 1 out of 1 in the Structure of the Triple (Lys(Beta)D3ALA, Asp(Beta)C8ALA, ASPCD2ALA) Mutant of the Src SH2 Domain Bound to the Pqpyeeipi Peptide


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Structure of the Triple (Lys(Beta)D3ALA, Asp(Beta)C8ALA, ASPCD2ALA) Mutant of the Src SH2 Domain Bound to the Pqpyeeipi Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co2000

b:49.3
occ:0.50
NE2 A:HIS235 2.2 11.2 1.0
CD2 A:HIS235 3.1 10.3 1.0
CE1 A:HIS235 3.3 9.7 1.0
CG A:HIS235 4.3 16.8 1.0
ND1 A:HIS235 4.4 17.4 1.0
O A:HOH1053 4.7 34.5 1.0

Reference:

O.Y.Lubman, G.Waksman. Dissection of the Energetic Coupling Across the Src SH2 Domain-Tyrosyl Phosphopeptide Interface. J.Mol.Biol. V. 316 291 2002.
ISSN: ISSN 0022-2836
PubMed: 11851339
DOI: 10.1006/JMBI.2001.5362
Page generated: Tue Jul 30 14:24:16 2024

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