Cobalt in PDB 1qzy: Human Methionine Aminopeptidase in Complex with Bengamide Inhibitor LAF153 and Cobalt

All present enzymatic activity of Human Methionine Aminopeptidase in Complex with Bengamide Inhibitor LAF153 and Cobalt:
3.4.11.18;

The structure of Human Methionine Aminopeptidase in Complex with Bengamide Inhibitor LAF153 and Cobalt, PDB code: 1qzy was solved by M.J.Eck, H.K.Song, A.Morollo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.36 / 1.60
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	90.610, 99.040, 101.383, 90.00, 90.00, 90.00
R / Rfree (%)	20.4 / 21.1

The binding sites of Cobalt atom in the Human Methionine Aminopeptidase in Complex with Bengamide Inhibitor LAF153 and Cobalt (pdb code 1qzy). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Human Methionine Aminopeptidase in Complex with Bengamide Inhibitor LAF153 and Cobalt, PDB code: 1qzy:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Human Methionine Aminopeptidase in Complex with Bengamide Inhibitor LAF153 and Cobalt


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Human Methionine Aminopeptidase in Complex with Bengamide Inhibitor LAF153 and Cobalt within 5.0Å range: probe atom residue distance (Å) B Occ A:Co479 b:17.8 occ:1.00 OD1 A:ASP262 2.1 15.6 1.0 OE1 A:GLU459 2.2 15.9 1.0 O24 A:TDE500 2.2 16.0 1.0 O23 A:TDE500 2.2 19.2 1.0 OD2 A:ASP251 2.2 15.0 1.0 OD1 A:ASP251 2.2 14.2 1.0 CG A:ASP251 2.5 14.2 1.0 CG A:ASP262 3.0 18.3 1.0 C15 A:TDE500 3.0 19.2 1.0 CD A:GLU459 3.0 18.0 1.0 C14 A:TDE500 3.1 18.4 1.0 OE2 A:GLU459 3.3 17.1 1.0 OD2 A:ASP262 3.3 19.0 1.0 CO A:CO480 3.4 18.9 1.0 OE1 A:GLU364 4.0 15.8 1.0 CB A:ASP251 4.1 12.5 1.0 CZ A:PHE219 4.1 13.7 1.0 NE2 A:GLN457 4.1 13.6 1.0 O A:HOH852 4.1 22.4 1.0 CE1 A:PHE219 4.4 14.2 1.0 CB A:ASP262 4.4 16.1 1.0 C16 A:TDE500 4.4 20.1 1.0 CG A:GLU459 4.4 15.0 1.0 C13 A:TDE500 4.4 19.5 1.0 CD A:GLU364 4.6 19.5 1.0 O22 A:TDE500 4.6 21.8 1.0 CB A:ALA264 4.6 14.2 1.0 OE2 A:GLU364 4.7 19.1 1.0 N A:CYS263 4.7 14.2 1.0 C A:ASP262 4.7 14.9 1.0 CA A:ASP262 4.8 15.8 1.0 CA A:ASP251 4.9 12.8 1.0 CB A:GLU459 4.9 15.3 1.0

Cobalt binding site 2 out of 2 in the Human Methionine Aminopeptidase in Complex with Bengamide Inhibitor LAF153 and Cobalt


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Human Methionine Aminopeptidase in Complex with Bengamide Inhibitor LAF153 and Cobalt within 5.0Å range: probe atom residue distance (Å) B Occ A:Co480 b:18.9 occ:1.00 OD2 A:ASP262 2.2 19.0 1.0 OE2 A:GLU364 2.2 19.1 1.0 NE2 A:HIS331 2.2 16.3 1.0 O23 A:TDE500 2.3 19.2 1.0 OE2 A:GLU459 2.3 17.1 1.0 O22 A:TDE500 2.5 21.8 1.0 CD A:GLU364 3.1 19.5 1.0 CG A:ASP262 3.1 18.3 1.0 CD2 A:HIS331 3.1 20.3 1.0 C14 A:TDE500 3.2 18.4 1.0 CE1 A:HIS331 3.3 18.4 1.0 C13 A:TDE500 3.3 19.5 1.0 CD A:GLU459 3.4 18.0 1.0 OE1 A:GLU364 3.4 15.8 1.0 CO A:CO479 3.4 17.8 1.0 OD1 A:ASP262 3.5 15.6 1.0 C15 A:TDE500 3.7 19.2 1.0 OE1 A:GLU459 3.8 15.9 1.0 C12 A:TDE500 3.9 18.8 1.0 CB A:ALA362 3.9 15.6 1.0 O24 A:TDE500 4.2 16.0 1.0 CB A:ASP262 4.2 16.1 1.0 CG A:HIS331 4.3 18.1 1.0 ND1 A:HIS331 4.3 17.0 1.0 CG A:GLU364 4.3 17.1 1.0 CG A:GLU459 4.7 15.0 1.0 NE2 A:HIS339 4.8 21.6 1.0 C10 A:TDE500 4.8 20.4 1.0 N9 A:TDE500 4.9 20.5 1.0 O21 A:TDE500 5.0 20.1 1.0 CB A:GLU364 5.0 18.0 1.0

H.Towbin, K.W.Bair, J.A.Decaprio, M.J.Eck, S.Kim, F.R.Kinder, A.Morollo, D.R.Mueller, P.Schindler, H.K.Song, J.Van Oostrum, R.W.Versace, H.Voshol, J.Wood, S.Zabludoff, P.E.Phillips. Proteomics-Based Target Identification: Bengamides As A New Class of Methionine Aminopeptidase Inhibitors. J.Biol.Chem. V. 278 52964 2003.
ISSN: ISSN 0021-9258
PubMed: 14534293
DOI: 10.1074/JBC.M309039200