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Cobalt in PDB 1t31: A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation

Enzymatic activity of A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation

All present enzymatic activity of A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation:
3.4.21.39;

Protein crystallography data

The structure of A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation, PDB code: 1t31 was solved by L.De Garavilla, M.N.Greco, E.C.Giardino, G.I.Wells, B.J.Haertlein, J.A.Kauffman, T.W.Corcoran, C.K.Derian, A.J.Eckardt, W.M.Abraham, N.Sukumar, Z.Chen, A.O.Pineda, F.S.Mathews, E.Di Cera, P.Andrade-Gordon, B.P.Damiano, B.E.Maryanoff, P.J.B.Pereira, Z.M.Wang, H.Rubin, R.Huber, W.Bode, N.M.Schechter, S.Strobl, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.00 / 1.90
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 46.417, 131.733, 49.219, 90.00, 90.00, 90.00
R / Rfree (%) 19.8 / 23.4

Cobalt Binding Sites:

The binding sites of Cobalt atom in the A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation (pdb code 1t31). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation, PDB code: 1t31:

Cobalt binding site 1 out of 1 in 1t31

Go back to Cobalt Binding Sites List in 1t31
Cobalt binding site 1 out of 1 in the A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co909

b:5.1
occ:0.50
O A:HOH1005 2.0 21.9 1.0
NE2 A:HIS25 2.1 15.4 1.0
OE2 A:GLU78 2.1 24.0 1.0
O A:HOH1002 2.8 33.8 0.5
CD2 A:HIS25 3.0 18.0 1.0
CE1 A:HIS25 3.1 19.9 1.0
CD A:GLU78 3.1 23.2 1.0
OE1 A:GLU78 3.5 24.2 1.0
CG A:HIS25 4.2 18.8 1.0
ND1 A:HIS25 4.2 19.4 1.0
CG A:GLU78 4.4 23.6 1.0
CB A:PRO24 4.5 18.4 1.0
O A:HOH1179 4.9 44.6 1.0
CB A:GLU78 4.9 20.6 1.0

Reference:

L.De Garavilla, M.N.Greco, N.Sukumar, Z.W.Chen, A.O.Pineda, F.S.Mathews, E.Di Cera, E.C.Giardino, G.I.Wells, B.J.Haertlein, J.A.Kauffman, T.W.Corcoran, C.K.Derian, A.J.Eckardt, B.P.Damiano, P.Andrade-Gordon, B.E.Maryanoff. A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase: Molecular Mechanisms and Anti-Inflammatory Activity in Vivo. J.Biol.Chem. V. 280 18001 2005.
ISSN: ISSN 0021-9258
PubMed: 15741158
DOI: 10.1074/JBC.M501302200
Page generated: Tue Jul 30 14:38:06 2024

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