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Cobalt in PDB 1uv5: Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime

Enzymatic activity of Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime

All present enzymatic activity of Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime:
2.7.1.37;

Protein crystallography data

The structure of Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime, PDB code: 1uv5 was solved by R.Dajani, L.H.Pearl, S.M.Roe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.46 / 2.80
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 98.333, 98.333, 198.017, 90.00, 90.00, 90.00
R / Rfree (%) 19.3 / 22.6

Other elements in 1uv5:

The structure of Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime also contains other interesting chemical elements:

Bromine (Br) 1 atom
Chlorine (Cl) 1 atom

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime (pdb code 1uv5). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime, PDB code: 1uv5:

Cobalt binding site 1 out of 1 in 1uv5

Go back to Cobalt Binding Sites List in 1uv5
Cobalt binding site 1 out of 1 in the Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Glycogen Synthase Kinase 3 Beta Complexed with 6-Bromoindirubin-3'- Oxime within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co1386

b:93.5
occ:1.00
 O A:HOH2112 2.5 99.3 1.0
O A:HOH2111 2.6 78.6 1.0
O A:HOH2110 2.6 60.5 1.0
O A:HOH2109 2.8 78.7 1.0
O A:HOH2050 3.4 70.7 1.0
O A:HOH2055 3.7 74.2 1.0
OD2 A:ASP200 3.8 67.5 1.0
OD2 A:ASP181 3.8 58.3 1.0
O A:HOH2052 4.0 0.2 1.0
N A:SER66 4.0 93.1 1.0
OG A:SER66 4.4 0.4 1.0
CD1 A:PHE67 4.4 99.6 1.0
CA A:GLY65 4.5 89.2 1.0
NZ A:LYS183 4.8 63.4 1.0
O A:HOH2011 4.8 79.7 1.0
C A:GLY65 4.8 91.1 1.0
CG A:ASP200 4.8 66.4 1.0
CE1 A:PHE67 4.9 98.4 1.0
CG A:ASP181 4.9 58.9 1.0
CB A:SER66 4.9 97.1 1.0

Reference:

L.Meijer, A.-L.Skaltsounis, P.Magiatis, P.Polychronopoulous, M.Knockaert, M.Leost, X.P.Ryan, C.A.Vonica, A.Brivanlou, R.Dajani, C.Crovace, C.Tarricone, A.Musacchio, S.M.Roe, L.H.Pearl, P.Greengard. Gsk-3-Selective Inhibitors Derived From Tyrian Purple Indurubins Chem.Biol. V. 10 1255 2003.
ISSN: ISSN 1074-5521
PubMed: 14700633
DOI: 10.1016/J.CHEMBIOL.2003.11.010
Page generated: Sun Dec 13 10:36:25 2020

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