Cobalt in PDB 1xrc: Crystal Structure of S-Adenosylmethionine Synthetase

All present enzymatic activity of Crystal Structure of S-Adenosylmethionine Synthetase:
2.5.1.6;

The structure of Crystal Structure of S-Adenosylmethionine Synthetase, PDB code: 1xrc was solved by F.Takusagawa, S.Kamitori, S.Misaki, G.D.Markham, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	10.00 / 3.00
Space group	P 62 2 2
Cell size a, b, c (Å), α, β, γ (°)	128.900, 128.900, 139.800, 90.00, 90.00, 120.00
R / Rfree (%)	19.7 / 25.8

The structure of Crystal Structure of S-Adenosylmethionine Synthetase also contains other interesting chemical elements:

Potassium

(K)

2 atoms

The binding sites of Cobalt atom in the Crystal Structure of S-Adenosylmethionine Synthetase (pdb code 1xrc). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Crystal Structure of S-Adenosylmethionine Synthetase, PDB code: 1xrc:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Crystal Structure of S-Adenosylmethionine Synthetase


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of S-Adenosylmethionine Synthetase within 5.0Å range: probe atom residue distance (Å) B Occ A:Co411 b:73.8 occ:1.00 O4 A:PO4384 2.1 61.7 1.0 O1 A:PO4384 2.1 59.5 1.0 O1 A:PO4385 2.2 76.5 1.0 P A:PO4384 2.7 55.1 1.0 OD2 A:ASP271 3.2 40.8 1.0 OD1 A:ASP271 3.4 34.6 1.0 P A:PO4385 3.6 70.8 1.0 OD2 A:ASP118 3.7 42.7 1.0 CG A:ASP271 3.7 33.6 1.0 O3 A:PO4384 3.8 60.7 1.0 O2 A:PO4384 3.8 53.2 1.0 O2 A:PO4385 4.2 77.7 1.0 HZ2 A:LYS265 4.2 24.0 0.0 HZ3 A:LYS265 4.3 24.0 0.0 O4 A:PO4385 4.4 70.7 1.0 O3 A:PO4385 4.4 72.2 1.0 NZ A:LYS265 4.8 24.4 1.0 CG A:ASP118 4.9 31.0 1.0 O A:GLN119 4.9 18.8 1.0

Cobalt binding site 2 out of 2 in the Crystal Structure of S-Adenosylmethionine Synthetase


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Crystal Structure of S-Adenosylmethionine Synthetase within 5.0Å range: probe atom residue distance (Å) B Occ A:Co412 b:85.7 occ:1.00 O3 A:PO4384 2.0 60.7 1.0 O2 A:PO4385 2.0 77.7 1.0 P A:PO4384 3.4 55.1 1.0 P A:PO4385 3.5 70.8 1.0 O4 A:PO4384 3.9 61.7 1.0 O1 A:PO4385 4.0 76.5 1.0 O1 A:PO4384 4.1 59.5 1.0 O3 A:PO4385 4.1 72.2 1.0 O2 A:PO4384 4.4 53.2 1.0 O4 A:PO4385 4.4 70.7 1.0 OE2 A:GLU42 4.7 37.5 1.0

F.Takusagawa, S.Kamitori, S.Misaki, G.D.Markham. Crystal Structure of S-Adenosylmethionine Synthetase. J.Biol.Chem. V. 271 136 1996.
ISSN: ISSN 0021-9258
PubMed: 8550549
DOI: 10.1074/JBC.271.1.136