Cobalt in PDB 1z3f: Structure of Ellipticine in Complex with A 6-Bp Dna

The structure of Structure of Ellipticine in Complex with A 6-Bp Dna, PDB code: 1z3f was solved by A.Canals, M.Purciolas, J.Aymami, M.Coll, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	16.66 / 1.50
Space group	P 65
Cell size a, b, c (Å), α, β, γ (°)	24.860, 24.860, 78.860, 90.00, 90.00, 120.00
R / Rfree (%)	22 / 24.2

The binding sites of Cobalt atom in the Structure of Ellipticine in Complex with A 6-Bp Dna (pdb code 1z3f). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 3 binding sites of Cobalt where determined in the Structure of Ellipticine in Complex with A 6-Bp Dna, PDB code: 1z3f:
Jump to Cobalt binding site number: 1; 2; 3;

Cobalt binding site 1 out of 3 in the Structure of Ellipticine in Complex with A 6-Bp Dna


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Structure of Ellipticine in Complex with A 6-Bp Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Co32 b:51.4 occ:1.00 N7 A:DG2 3.0 27.8 1.0 C8 A:DG2 3.9 26.0 1.0 O6 A:DG2 3.9 25.8 1.0 C5 A:DG2 4.0 25.7 1.0 O4 B:DT4 4.3 27.8 1.0 C6 A:DG2 4.3 26.1 1.0 C1 B:EL42 4.5 34.2 1.0 O A:HOH42 4.6 35.2 1.0 C6 B:EL42 5.0 31.1 1.0

Cobalt binding site 2 out of 3 in the Structure of Ellipticine in Complex with A 6-Bp Dna


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Structure of Ellipticine in Complex with A 6-Bp Dna within 5.0Å range: probe atom residue distance (Å) B Occ B:Co31 b:44.9 occ:1.00 N7 B:DG2 2.5 27.6 1.0 C8 B:DG2 3.5 25.9 1.0 C5 B:DG2 3.6 25.2 1.0 O6 B:DG2 3.7 26.3 1.0 C6 B:DG2 4.0 26.2 1.0 C1 A:EL41 4.2 30.6 1.0 O4 A:DT4 4.3 27.4 1.0 O B:HOH47 4.5 41.3 1.0 O B:HOH43 4.6 34.8 1.0 N9 B:DG2 4.7 26.8 1.0 C6 A:EL41 4.7 31.8 1.0 O A:HOH50 4.7 44.5 1.0 C4 B:DG2 4.7 25.8 1.0 C2 A:EL41 4.8 32.7 1.0 N6 B:DA3 4.9 25.1 1.0

Cobalt binding site 3 out of 3 in the Structure of Ellipticine in Complex with A 6-Bp Dna


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 3 of Structure of Ellipticine in Complex with A 6-Bp Dna within 5.0Å range: probe atom residue distance (Å) B Occ B:Co33 b:37.7 occ:1.00 OP1 B:DA3 4.2 37.4 1.0 O B:HOH46 4.8 39.4 1.0

A.Canals, M.Purciolas, J.Aymami, M.Coll. The Anticancer Agent Ellipticine Unwinds Dna By Intercalative Binding in An Orientation Parallel to Base Pairs. Acta Crystallogr.,Sect.D V. 61 1009 2005.
ISSN: ISSN 0907-4449
PubMed: 15983425
DOI: 10.1107/S0907444905015404