Chemical elements
  Cobalt
    Isotopes
    Energy
    Production
    Preparation
    Application
    Physical Properties
    Chemical Properties
    Compounds
    PDB 1a0c-1epy
    PDB 1et4-1k7y
    PDB 1k98-1r6x
    PDB 1r8k-1v9b
    PDB 1vl3-212d
    PDB 222d-2eff
      222d
      232d
      259l
      2adu
      2amx
      2b1d
      2b3h
      2b3k
      2b57
      2bb5
      2bb6
      2bbc
      2bcy
      2bcz
      2bdi
      2bo7
      2bob
      2boc
      2c79
      2cd5
      2cd6
      2cf4
      2cla
      2d2g
      2d2h
      2d2j
      2d2k
      2d2l
      2d2x
      2dd5
      2dds
      2dfi
      2djl
      2djx
      2dpc
      2dpp
      2dtr
      2dxb
      2dxc
      2dxl
      2e68
      2e6a
      2e6d
      2e6f
      2ees
      2eet
      2eeu
      2eev
      2eew
      2eff
    PDB 2ehd-2j3z
    PDB 2j4j-2r1p
    PDB 2r2s-331d
    PDB 362d-3fqw
    PDB 3ft6-3igy
    PDB 3igz-3o0n
    PDB 3o0o-4req
    PDB 4xim-9icb

Cobalt in the structure of Human Methionine Aminopeptidase Complex With 4-Aryl-1,2,3- Triazole Inhibitor (pdb 2adu)






The binding sites of Cobalt atom in the structure of Human Methionine Aminopeptidase Complex With 4-Aryl-1,2,3- Triazole Inhibitor (pdb code 2adu). This binding sites where shown with 5.0 Angstroms radius around Cobalt atom.
The 2adu structure was solved by L.S.KALLANDER, Q.LU, W.CHEN, T.TOMASZEK, G.YANG, D.TEW, T.D.MEEK, G.A.HOFMANN, C.K.SCHULZ-PRITCHARD, W.W.SMITH, C.A.JANSON, M.D.RYAN, G.F.ZHANG, K.O.JOHANSON, R.B.KIRKPATRICK, T.F.HO, P.W.FISHER, M.R.MATTERN, R.K.JOHNSON, M.J.HANSBURY, J.D.WINKLER, K.W.WARD, D.F.VEBER, S.K.THOMPSON, with X-Ray Crystallography technique, brief refinement statistics is given in the table below:
Resolution (A)99.0-1.9
Space groupC2221
a (A)89.819
b (A)99.264
c (A)101.282
alpha (°)90.00
beta (°)90.00
gamma (°)90.00
Rfactor (%)33.5
Rfree (%)35.5


Cobalt Binding Sites:

Cobalt binding site 1 out of 2 in 2adu


Cobalt binding site 1 out of 2 in 2adu
Click to enlarge
stereopicture of Cobalt binding site 1 out of 2 in 2adu
Click to enlarge
Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Cobalt in the PDB 2adu. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Cobalt atom, shown by VdW sphere
Residues shown as a stick model or VDW spheres: A: Phe219, A: Asp251, A: Asp262, A: Cys263, A: Ala264, A: Glu364, A: Gln457, A: Glu459, A: Co502, A: R20906, A: Hoh653,

conact list:


AtomAtomDistance (A)
CoCE2 A:Phe2194.60
CoCZ A:Phe2193.77
CoCE1 A:Phe2194.30
CoCB A:Asp2514.08
CoOD2 A:Asp2512.39
CoOD1 A:Asp2512.10
CoCG A:Asp2512.56
CoCA A:Asp2514.83
CoCB A:Asp2624.22
CoOD2 A:Asp2622.93
CoC A:Asp2624.72
CoOD1 A:Asp2621.90
CoCG A:Asp2622.76
CoCA A:Asp2624.73
CoN A:Cys2634.64
CoCB A:Ala2644.60
CoOE1 A:Glu3644.18
CoOE2 A:Glu3644.25
CoCD A:Glu3644.51
CoNE2 A:Gln4574.26
CoOE1 A:Glu4591.84
CoCB A:Glu4594.68
CoOE2 A:Glu4593.22
CoCD A:Glu4592.84
CoCG A:Glu4594.18
CoCO A:Co5023.28
CoN10 A:R209062.79
CoN9 A:R209061.96
CoN6 A:R209064.00
CoC5 A:R209063.10
CoC2 A:R209064.21
CoO A:Hoh6534.42

interactive model:


Cobalt binding site 2 out of 2 in 2adu


Cobalt binding site 2 out of 2 in 2adu
Click to enlarge
stereopicture of Cobalt binding site 2 out of 2 in 2adu
Click to enlarge
Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 2 of Cobalt in the PDB 2adu. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Cobalt atom, shown by VdW sphere
Residues shown as a stick model or VDW spheres: A: Asp251, A: Asp262, A: His331, A: His339, A: Ala362, A: Glu364, A: Glu459, A: Co501, A: R20906, A: Hoh653, A: Hoh671,

conact list:


AtomAtomDistance (A)
CoOD2 A:Asp2514.98
CoCB A:Asp2624.27
CoOD2 A:Asp2621.96
CoOD1 A:Asp2623.59
CoCG A:Asp2623.07
CoNE2 A:His3311.98
CoND1 A:His3314.03
CoCD2 A:His3313.03
CoCE1 A:His3312.90
CoCG A:His3314.12
CoNE2 A:His3394.46
CoCB A:Ala3623.89
CoOE1 A:Glu3643.58
CoCB A:Glu3644.80
CoOE2 A:Glu3641.92
CoCD A:Glu3642.96
CoCG A:Glu3644.04
CoOE1 A:Glu4593.28
CoOE2 A:Glu4591.83
CoCD A:Glu4592.88
CoCG A:Glu4594.22
CoCO A:Co5013.28
CoN10 A:R209062.05
CoN9 A:R209063.00
CoN6 A:R209063.08
CoC5 A:R209064.16
CoC2 A:R209064.26
CoO A:Hoh6534.32
CoO A:Hoh6714.66

interactive model:




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