Cobalt in the structure of Crystal Structure of Trypanosoma Cruzi Dihydroorotate Dehydrogenase in Complex With Orotate (pdb 2e6a)

The binding sites of Cobalt atom in the structure of Crystal Structure of Trypanosoma Cruzi Dihydroorotate Dehydrogenase in Complex With Orotate (pdb code 2e6a). This binding sites where shown with 5.0 Angstroms radius around Cobalt atom. The 2e6a structure was solved by D.K.INAOKA, H.SHIMIZU, K.SAKAMOTO, T.SHIBA, G.KURISU, T.NARA, T.AOKI, S.HARADA, K.KITA, with X-Ray Crystallography technique, brief refinement statistics is given in the table below: Resolution (A) 49.5-1.6 Space group P212121 a (A) 68.248 b (A) 71.881 c (A) 123.574 alpha (°) 90.00 beta (°) 90.00 gamma (°) 90.00 Rfactor (%) 16.2 Rfree (%) 19.2 Cobalt Binding Sites: Cobalt binding site 1 out of 1 in 2e6a Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Cobalt in the PDB 2e6a. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Cobalt atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Gln275, A: Glu276, A: Nco1351, A: Hoh1428, conact list: Atom Atom Distance (A) Co O A:Gln275 3.87 Co O A:Glu276 4.20 Co C A:Glu276 4.87 Co N1 A:Nco1351 1.98 Co N6 A:Nco1351 2.01 Co CO A:Nco1351 0.00 Co N3 A:Nco1351 1.98 Co N2 A:Nco1351 2.00 Co N5 A:Nco1351 2.00 Co N4 A:Nco1351 2.01 Co O A:Hoh1428 4.42 interactive model: