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Cobalt in PDB 2gg2: Novel Bacterial Methionine Aminopeptidase Inhibitors

Enzymatic activity of Novel Bacterial Methionine Aminopeptidase Inhibitors

All present enzymatic activity of Novel Bacterial Methionine Aminopeptidase Inhibitors:
3.4.11.18;

Protein crystallography data

The structure of Novel Bacterial Methionine Aminopeptidase Inhibitors, PDB code: 2gg2 was solved by A.G.Evdokimov, M.E.Pokross, R.L.Walter, M.Mekel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.06 / 1.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 39.372, 63.204, 52.508, 90.00, 109.55, 90.00
R / Rfree (%) 13.6 / 15.3

Other elements in 2gg2:

The structure of Novel Bacterial Methionine Aminopeptidase Inhibitors also contains other interesting chemical elements:

Fluorine (F) 3 atoms
Sodium (Na) 1 atom

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Novel Bacterial Methionine Aminopeptidase Inhibitors (pdb code 2gg2). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Novel Bacterial Methionine Aminopeptidase Inhibitors, PDB code: 2gg2:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in 2gg2

Go back to Cobalt Binding Sites List in 2gg2
Cobalt binding site 1 out of 2 in the Novel Bacterial Methionine Aminopeptidase Inhibitors


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Novel Bacterial Methionine Aminopeptidase Inhibitors within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co301

b:9.4
occ:1.00
N1 A:U12801 2.0 13.0 1.0
OE2 A:GLU235 2.0 6.8 0.5
OE2 A:GLU204 2.1 8.7 0.5
NE2 A:HIS171 2.1 9.6 1.0
OD2 A:ASP108 2.1 11.2 1.0
OE1 A:GLU235 2.1 18.4 0.5
OE1 A:GLU204 2.2 12.8 0.5
CD A:GLU204 2.8 10.1 0.5
CD A:GLU235 3.0 7.4 0.5
N4 A:U12801 3.0 13.5 1.0
C2 A:U12801 3.0 14.0 1.0
CD A:GLU204 3.0 11.1 0.5
OE1 A:GLU204 3.0 12.0 0.5
CE1 A:HIS171 3.0 9.9 1.0
CG A:ASP108 3.0 9.2 1.0
CD2 A:HIS171 3.1 9.4 1.0
OE2 A:GLU204 3.2 14.6 0.5
CD A:GLU235 3.3 14.7 0.5
CO A:CO302 3.3 11.1 1.0
OE1 A:GLU235 3.3 9.2 0.5
N2 A:U12801 3.4 14.6 1.0
OD1 A:ASP108 3.5 11.0 1.0
OG1 A:THR202 3.8 9.3 1.0
CG2 A:THR202 4.0 9.8 1.0
OE2 A:GLU235 4.1 13.4 0.5
C3 A:U12801 4.1 13.6 1.0
ND1 A:HIS171 4.1 10.6 1.0
CB A:THR202 4.2 8.7 1.0
CG A:GLU235 4.2 11.0 0.5
CG A:GLU204 4.2 10.4 0.5
CG A:HIS171 4.2 10.3 1.0
C1 A:U12801 4.2 14.1 1.0
CB A:ASP108 4.2 9.5 1.0
CG A:GLU235 4.3 7.0 0.5
CG A:GLU204 4.4 8.8 0.5
O A:HOH840 4.5 17.7 1.0
CE1 A:PHE177 4.7 13.3 1.0
CB A:GLU204 4.9 8.5 0.5
CB A:GLU204 5.0 9.3 0.5

Cobalt binding site 2 out of 2 in 2gg2

Go back to Cobalt Binding Sites List in 2gg2
Cobalt binding site 2 out of 2 in the Novel Bacterial Methionine Aminopeptidase Inhibitors


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Novel Bacterial Methionine Aminopeptidase Inhibitors within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co302

b:11.1
occ:1.00
N4 A:U12801 1.8 13.5 1.0
OD1 A:ASP97 2.0 13.1 1.0
OD1 A:ASP108 2.0 11.0 1.0
OE1 A:GLU235 2.1 9.2 0.5
OE2 A:GLU235 2.1 13.4 0.5
OE1 A:GLU235 2.3 18.4 0.5
OD2 A:ASP97 2.4 13.3 1.0
CD A:GLU235 2.5 14.7 0.5
CG A:ASP97 2.6 10.3 1.0
N1 A:U12801 2.7 13.0 1.0
C3 A:U12801 2.9 13.6 1.0
CG A:ASP108 2.9 9.2 1.0
CD A:GLU235 3.0 7.4 0.5
OE2 A:GLU235 3.2 6.8 0.5
OD2 A:ASP108 3.2 11.2 1.0
CO A:CO301 3.3 9.4 1.0
N5 A:U12801 3.3 16.1 1.0
OG1 A:THR99 3.8 14.6 1.0
C2 A:U12801 3.8 14.0 1.0
OE1 A:GLU204 3.9 12.0 0.5
O A:HOH1127 3.9 10.9 1.0
C1 A:U12801 4.0 14.1 1.0
CG A:GLU235 4.1 11.0 0.5
CB A:ASP97 4.1 9.2 1.0
N A:THR109 4.2 8.4 1.0
CB A:ASP108 4.3 9.5 1.0
O A:THR109 4.3 8.9 1.0
CG A:GLU235 4.4 7.0 0.5
O A:VAL98 4.5 11.9 1.0
C A:ASP108 4.6 8.9 1.0
C A:THR109 4.6 7.7 1.0
OE2 A:GLU204 4.6 14.6 0.5
CD A:GLU204 4.7 10.1 0.5
CA A:ASP108 4.7 9.0 1.0
OE2 A:GLU204 4.7 8.7 0.5
O A:HOH840 4.7 17.7 1.0
O A:HOH962 4.8 13.4 1.0
OE1 A:GLU204 4.8 12.8 0.5
CA A:ASP97 4.8 8.4 1.0
CB A:GLU235 4.8 8.7 0.5
CB A:GLU235 4.8 8.0 0.5
CA A:THR109 4.8 8.0 1.0
N A:VAL98 4.9 9.2 1.0
C A:ASP97 4.9 8.9 1.0
CB A:SER110 5.0 8.2 1.0
CD A:GLU204 5.0 11.1 0.5
C A:VAL98 5.0 9.8 1.0

Reference:

A.G.Evdokimov, M.Pokross, R.L.Walter, M.Mekel, B.L.Barnett, J.Amburgey, W.L.Seibel, S.J.Soper, J.F.Djung, N.Fairweather, C.Diven, V.Rastogi, L.Grinius, C.Klanke, R.Siehnel, T.Twinem, R.Andrews, A.Curnow. Serendipitous Discovery of Novel Bacterial Methionine Aminopeptidase Inhibitors. Proteins V. 66 538 2007.
ISSN: ISSN 0887-3585
PubMed: 17120228
DOI: 10.1002/PROT.21207
Page generated: Sun Dec 13 10:37:56 2020

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