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Cobalt in PDB 2ggb: Novel Bacterial Methionine Aminopeptidase Inhibitors

Enzymatic activity of Novel Bacterial Methionine Aminopeptidase Inhibitors

All present enzymatic activity of Novel Bacterial Methionine Aminopeptidase Inhibitors:
3.4.11.18;

Protein crystallography data

The structure of Novel Bacterial Methionine Aminopeptidase Inhibitors, PDB code: 2ggb was solved by A.G.Evdokimov, M.E.Pokross, R.L.Walter, M.Mekel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.73 / 2.13
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 38.722, 61.454, 53.308, 90.00, 107.08, 90.00
R / Rfree (%) 18.5 / 25.9

Other elements in 2ggb:

The structure of Novel Bacterial Methionine Aminopeptidase Inhibitors also contains other interesting chemical elements:

Sodium (Na) 1 atom

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Novel Bacterial Methionine Aminopeptidase Inhibitors (pdb code 2ggb). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Novel Bacterial Methionine Aminopeptidase Inhibitors, PDB code: 2ggb:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in 2ggb

Go back to Cobalt Binding Sites List in 2ggb
Cobalt binding site 1 out of 2 in the Novel Bacterial Methionine Aminopeptidase Inhibitors


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Novel Bacterial Methionine Aminopeptidase Inhibitors within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co301

b:14.8
occ:1.00
O1 A:U17304 1.9 17.4 1.0
OE1 A:GLU235 2.1 15.2 1.0
OD1 A:ASP108 2.1 11.2 1.0
NE2 A:HIS171 2.1 17.7 1.0
OE2 A:GLU204 2.3 13.6 1.0
O2 A:U17304 2.9 21.5 1.0
CD2 A:HIS171 3.0 4.0 1.0
CG A:ASP108 3.0 14.2 1.0
C9 A:U17304 3.1 24.1 1.0
CD A:GLU204 3.1 16.3 1.0
CD A:GLU235 3.1 18.5 1.0
CE1 A:HIS171 3.2 9.6 1.0
OE1 A:GLU204 3.2 19.1 1.0
C10 A:U17304 3.3 20.9 1.0
CO A:CO302 3.3 12.5 1.0
OD2 A:ASP108 3.3 13.3 1.0
OE2 A:GLU235 3.4 8.6 1.0
C7 A:U17304 3.7 18.2 1.0
OG1 A:THR202 3.8 11.8 1.0
CG2 A:THR202 4.1 14.2 1.0
CG A:HIS171 4.2 13.4 1.0
N1 A:U17304 4.2 16.7 1.0
ND1 A:HIS171 4.2 15.8 1.0
CB A:THR202 4.3 14.5 1.0
CB A:ASP108 4.3 8.9 1.0
N2 A:U17304 4.3 22.6 1.0
CG A:GLU235 4.4 17.4 1.0
CG A:GLU204 4.5 16.4 1.0
NE2 A:HIS178 4.5 19.1 1.0
CE1 A:PHE177 4.9 22.8 1.0
CD2 A:HIS178 4.9 22.0 1.0
C3 A:U17304 5.0 24.3 1.0

Cobalt binding site 2 out of 2 in 2ggb

Go back to Cobalt Binding Sites List in 2ggb
Cobalt binding site 2 out of 2 in the Novel Bacterial Methionine Aminopeptidase Inhibitors


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Novel Bacterial Methionine Aminopeptidase Inhibitors within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co302

b:12.5
occ:1.00
OD2 A:ASP108 2.0 13.3 1.0
N1 A:U17304 2.0 16.7 1.0
OE2 A:GLU235 2.1 8.6 1.0
OD1 A:ASP97 2.1 13.2 1.0
O1 A:U17304 2.2 17.4 1.0
OD2 A:ASP97 2.4 11.6 1.0
CG A:ASP97 2.6 14.9 1.0
C9 A:U17304 2.8 24.1 1.0
C7 A:U17304 2.8 18.2 1.0
CD A:GLU235 3.0 18.5 1.0
CG A:ASP108 3.1 14.2 1.0
OE1 A:GLU235 3.3 15.2 1.0
CO A:CO301 3.3 14.8 1.0
OD1 A:ASP108 3.4 11.2 1.0
OE1 A:GLU204 3.8 19.1 1.0
OG1 A:THR99 3.9 12.7 1.0
O A:HOH411 3.9 13.1 1.0
CB A:ASP97 4.1 11.9 1.0
C10 A:U17304 4.2 20.9 1.0
C3 A:U17304 4.3 24.3 1.0
CG A:GLU235 4.3 17.4 1.0
N A:THR109 4.4 13.5 1.0
O A:VAL98 4.4 13.6 1.0
O2 A:U17304 4.4 21.5 1.0
CB A:ASP108 4.5 8.9 1.0
CD A:GLU204 4.6 16.3 1.0
OE2 A:GLU204 4.7 13.6 1.0
O A:THR109 4.7 13.0 1.0
O A:HOH341 4.7 8.0 1.0
C A:ASP108 4.7 11.5 1.0
CB A:GLU235 4.8 10.2 1.0
C A:THR109 4.8 11.7 1.0
CA A:ASP97 4.8 13.7 1.0
CA A:ASP108 4.9 12.7 1.0
CA A:THR109 4.9 12.1 1.0
C A:ASP97 4.9 13.8 1.0
N A:VAL98 5.0 14.9 1.0

Reference:

A.G.Evdokimov, M.Pokross, R.L.Walter, M.Mekel, B.L.Barnett, J.Amburgey, W.L.Seibel, S.J.Soper, J.F.Djung, N.Fairweather, C.Diven, V.Rastogi, L.Grinius, C.Klanke, R.Siehnel, T.Twinem, R.Andrews, A.Curnow. Serendipitous Discovery of Novel Bacterial Methionine Aminopeptidase Inhibitors. Proteins V. 66 538 2007.
ISSN: ISSN 0887-3585
PubMed: 17120228
DOI: 10.1002/PROT.21207
Page generated: Tue Jul 30 15:13:11 2024

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