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Cobalt in PDB 2nq7: Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide

Enzymatic activity of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide

All present enzymatic activity of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide:
3.4.11.18;

Protein crystallography data

The structure of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide, PDB code: 2nq7 was solved by A.Addlagatta, B.W.Matthews, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.60
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 47.317, 77.442, 47.221, 90.00, 92.31, 90.00
R / Rfree (%) 19.5 / 22.7

Other elements in 2nq7:

The structure of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide also contains other interesting chemical elements:

Potassium (K) 1 atom

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide (pdb code 2nq7). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 3 binding sites of Cobalt where determined in the Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide, PDB code: 2nq7:
Jump to Cobalt binding site number: 1; 2; 3;

Cobalt binding site 1 out of 3 in 2nq7

Go back to Cobalt Binding Sites List in 2nq7
Cobalt binding site 1 out of 3 in the Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co401

b:11.4
occ:1.00
 OD1 A:ASP240 2.0 10.4 1.0
O A:HOH624 2.1 15.2 1.0
OE1 A:GLU367 2.2 11.7 1.0
OD1 A:ASP229 2.2 10.0 1.0
O A:HOH626 2.3 12.3 1.0
OD2 A:ASP229 2.4 14.9 1.0
CG A:ASP229 2.6 12.9 1.0
CG A:ASP240 2.9 10.8 1.0
OD2 A:ASP240 3.0 10.0 1.0
CD A:GLU367 3.1 11.4 1.0
CO A:CO402 3.2 12.8 1.0
OE2 A:GLU367 3.2 10.9 1.0
O A:HOH476 3.8 16.2 1.0
OG1 A:THR231 4.0 12.0 1.0
CB A:ASP229 4.1 11.4 1.0
ND2 A:ASN242 4.1 12.6 1.0
O A:HOH625 4.2 13.6 1.0
OE2 A:GLU336 4.3 17.9 1.0
CB A:ASP240 4.3 11.8 1.0
O A:LEU241 4.4 10.9 1.0
N A:LEU241 4.4 10.5 1.0
CG A:GLU367 4.5 13.0 1.0
O A:ILE230 4.5 10.0 1.0
O A:HOH494 4.5 17.9 1.0
O A:HOH480 4.5 14.5 1.0
OE1 A:GLU336 4.5 11.3 1.0
C A:LEU241 4.7 11.0 1.0
O A:HOH547 4.7 17.0 1.0
CD A:GLU336 4.7 21.1 1.0
C A:ASP240 4.7 10.2 1.0
CA A:ASP240 4.8 10.8 1.0
CA A:ASP229 4.8 9.5 1.0
CB A:ASN242 4.9 10.5 1.0
CA A:LEU241 4.9 9.4 1.0
N A:ILE230 5.0 10.3 1.0

Cobalt binding site 2 out of 3 in 2nq7

Go back to Cobalt Binding Sites List in 2nq7
Cobalt binding site 2 out of 3 in the Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co402

b:12.8
occ:1.00
 O A:HOH624 1.9 15.2 1.0
OE2 A:GLU367 2.0 10.9 1.0
OD2 A:ASP240 2.0 10.0 1.0
NE2 A:HIS303 2.1 9.8 1.0
OE1 A:GLU336 2.2 11.3 1.0
CG A:ASP240 3.0 10.8 1.0
CD A:GLU367 3.0 11.4 1.0
CD2 A:HIS303 3.1 15.0 1.0
CE1 A:HIS303 3.1 16.4 1.0
CD A:GLU336 3.1 21.1 1.0
CO A:CO401 3.2 11.4 1.0
OE1 A:GLU367 3.4 11.7 1.0
OD1 A:ASP240 3.4 10.4 1.0
OE2 A:GLU336 3.5 17.9 1.0
OG1 A:THR334 3.6 14.9 1.0
O A:HOH476 3.8 16.2 1.0
CG2 A:THR334 3.9 11.4 1.0
CB A:THR334 4.1 13.0 1.0
CB A:ASP240 4.2 11.8 1.0
ND1 A:HIS303 4.2 14.1 1.0
CG A:HIS303 4.2 15.7 1.0
O A:HOH626 4.3 12.3 1.0
CG A:GLU367 4.3 13.0 1.0
CG A:GLU336 4.4 14.3 1.0
O A:HOH547 4.8 17.0 1.0
NE2 A:HIS310 4.8 17.6 1.0
CB A:GLU336 4.9 11.6 1.0
OD2 A:ASP229 5.0 14.9 1.0
CD2 A:HIS310 5.0 17.4 1.0

Cobalt binding site 3 out of 3 in 2nq7

Go back to Cobalt Binding Sites List in 2nq7
Cobalt binding site 3 out of 3 in the Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 3 of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co403

b:14.7
occ:1.00
 N3 A:HM5410 2.1 17.0 1.0
NE2 A:HIS212 2.1 14.0 1.0
O A:HOH547 2.2 17.0 1.0
O A:HOH476 2.2 16.2 1.0
N2 A:HM5410 2.3 25.5 1.0
O A:HOH625 2.3 13.6 1.0
C5 A:HM5410 3.0 23.0 1.0
C4 A:HM5410 3.1 20.3 1.0
CD2 A:HIS212 3.1 14.2 1.0
C3 A:HM5410 3.1 17.1 1.0
CE1 A:HIS212 3.1 17.8 1.0
C6 A:HM5410 3.2 23.9 1.0
N1 A:HM5410 3.3 18.8 1.0
O A:HOH624 3.9 15.2 1.0
NE2 A:HIS310 4.0 17.6 1.0
ND1 A:HIS212 4.2 15.0 1.0
CG A:HIS212 4.2 14.4 1.0
O1 A:HM5410 4.2 20.9 1.0
O A:HOH480 4.3 14.5 1.0
C9 A:HM5410 4.4 26.4 1.0
C7 A:HM5410 4.4 28.1 1.0
O A:HOH626 4.4 12.3 1.0
OD2 A:ASP229 4.5 14.9 1.0
OE2 A:GLU336 4.6 17.9 1.0
CE1 A:HIS310 4.7 18.9 1.0
C2 A:HM5410 4.7 23.2 1.0
S A:HM5410 4.7 20.7 1.0
C8 A:HM5410 4.9 26.2 1.0

Reference:

X.Hu, A.Addlagatta, J.Lu, B.W.Matthews, J.O.Liu. Elucidation of the Function of Type 1 Human Methionine Aminopeptidase During Cell Cycle Progression. Proc.Natl.Acad.Sci.Usa V. 103 18148 2006.
ISSN: ISSN 0027-8424
PubMed: 17114291
DOI: 10.1073/PNAS.0608389103
Page generated: Tue Jul 30 15:19:28 2024

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