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Cobalt in PDB 2vor: Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp

Enzymatic activity of Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp

All present enzymatic activity of Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp:
6.3.2.17;

Protein crystallography data

The structure of Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp, PDB code: 2vor was solved by P.G.Young, E.N.Baker, P.Metcalf, C.A.Smith, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 79.56 / 2.3
Space group P 21 3
Cell size a, b, c (Å), α, β, γ (°) 112.396, 112.396, 112.396, 90.00, 90.00, 90.00
R / Rfree (%) 17.6 / 22.3

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp (pdb code 2vor). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 4 binding sites of Cobalt where determined in the Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp, PDB code: 2vor:
Jump to Cobalt binding site number: 1; 2; 3; 4;

Cobalt binding site 1 out of 4 in 2vor

Go back to Cobalt Binding Sites List in 2vor
Cobalt binding site 1 out of 4 in the Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co1491

b:22.4
occ:0.33
 OD2 A:ASP326 1.9 28.7 1.0
O A:HOH2116 2.0 25.6 1.0
CG A:ASP326 3.0 32.3 1.0
OD1 A:ASP326 3.3 32.9 1.0
CB A:ASP326 4.3 34.0 1.0

Cobalt binding site 2 out of 4 in 2vor

Go back to Cobalt Binding Sites List in 2vor
Cobalt binding site 2 out of 4 in the Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co1492

b:31.6
occ:1.00
 O1G A:ACP1490 2.0 34.9 1.0
O2B A:ACP1490 2.1 27.1 1.0
O A:SER100 2.2 29.9 1.0
OE2 A:GLU176 2.2 39.8 1.0
OG1 A:THR78 2.4 26.1 1.0
CD A:GLU176 3.2 41.6 1.0
PG A:ACP1490 3.2 49.7 1.0
PB A:ACP1490 3.4 30.9 1.0
CB A:THR78 3.4 25.4 1.0
C A:SER100 3.4 31.8 1.0
OE1 A:GLU176 3.4 37.9 1.0
C3B A:ACP1490 3.5 39.3 1.0
O2G A:ACP1490 3.7 45.5 1.0
N A:THR78 3.8 25.6 1.0
CD A:PRO101 3.9 30.7 1.0
CA A:THR78 4.0 24.7 1.0
N A:PRO101 4.1 33.1 1.0
O A:HOH2041 4.1 39.8 1.0
O1B A:ACP1490 4.3 33.3 1.0
O1A A:ACP1490 4.4 31.1 1.0
N A:SER100 4.4 31.2 1.0
O3G A:ACP1490 4.4 45.1 1.0
CA A:SER100 4.5 32.3 1.0
CG A:GLU176 4.5 36.0 1.0
O3A A:ACP1490 4.5 31.5 1.0
NH2 A:ARG340 4.5 50.4 1.0
CE A:LYS77 4.6 25.2 1.0
CG2 A:THR78 4.6 23.4 1.0
NZ A:LYS77 4.7 23.8 1.0
PA A:ACP1490 4.7 31.8 1.0
CB A:LYS77 4.7 23.5 1.0
C A:LYS77 4.8 24.8 1.0

Cobalt binding site 3 out of 4 in 2vor

Go back to Cobalt Binding Sites List in 2vor
Cobalt binding site 3 out of 4 in the Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 3 of Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co1493

b:60.0
occ:1.00
 O A:HOH2118 1.9 40.5 1.0
O A:HOH2119 2.2 48.3 1.0
NE2 A:HIS203 2.3 45.0 1.0
OD1 A:ASP205 2.3 41.3 1.0
O A:HOH2117 2.3 58.9 1.0
CE1 A:HIS203 3.1 46.9 1.0
CG A:ASP205 3.3 39.1 1.0
CD2 A:HIS203 3.4 43.3 1.0
OD2 A:ASP205 3.6 40.2 1.0
ND1 A:HIS203 4.3 45.1 1.0
CG A:HIS203 4.4 43.9 1.0
CB A:ASP205 4.6 37.8 1.0
O A:VAL204 4.9 37.4 1.0
CA A:ASP205 5.0 37.1 1.0

Cobalt binding site 4 out of 4 in 2vor

Go back to Cobalt Binding Sites List in 2vor
Cobalt binding site 4 out of 4 in the Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 4 of Crystal Structures of Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed with Adp and Amppcp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co1494

b:56.5
occ:1.00
 OD1 A:ASP457 2.0 28.1 1.0
O A:HOH2120 2.2 43.0 1.0
OD1 A:ASP455 2.3 41.9 1.0
CG A:ASP457 3.0 36.0 1.0
CG A:ASP455 3.1 44.0 1.0
OD2 A:ASP457 3.2 31.2 1.0
OD2 A:ASP455 3.3 44.5 1.0
CB A:ASP457 4.4 39.7 1.0
N A:ASP457 4.5 41.5 1.0
CB A:ASP455 4.6 43.5 1.0
CG2 A:VAL458 4.6 45.5 1.0
CA A:ASP457 4.8 41.5 1.0
CD A:PRO456 4.9 42.0 1.0
C A:ASP455 4.9 43.0 1.0
CA A:ASP455 5.0 43.2 1.0

Reference:

P.G.Young, C.A.Smith, P.Metcalf, E.N.Baker. Structures of Mycobacterium Tuberculosisfolylpolyglutamate Synthase Complexed with Adp and Amppcp. Acta Crystallogr.,Sect.D V. 64 745 2008.
ISSN: ISSN 0907-4449
PubMed: 18566510
DOI: 10.1107/S0907444908012262
Page generated: Sun Dec 13 10:39:03 2020

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