Cobalt in PDB 2xg5: E. Coli P Pilus Chaperone-Subunit Complex Papd-Paph Bound to Pilus Biogenesis Inhibitor, Pilicide 5D

The structure of E. Coli P Pilus Chaperone-Subunit Complex Papd-Paph Bound to Pilus Biogenesis Inhibitor, Pilicide 5D, PDB code: 2xg5 was solved by H.Remaut, G.Phan, F.Buelens, E.Chorell, J.S.Pinkner, S.Edvinsson, F.Almqvist, S.J.Hultgren, G.Waksman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.00
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	103.610, 149.830, 82.900, 90.00, 90.00, 90.00
R / Rfree (%)	18.928 / 21.503

The binding sites of Cobalt atom in the E. Coli P Pilus Chaperone-Subunit Complex Papd-Paph Bound to Pilus Biogenesis Inhibitor, Pilicide 5D (pdb code 2xg5). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the E. Coli P Pilus Chaperone-Subunit Complex Papd-Paph Bound to Pilus Biogenesis Inhibitor, Pilicide 5D, PDB code: 2xg5:

Cobalt binding site 1 out of 1 in the E. Coli P Pilus Chaperone-Subunit Complex Papd-Paph Bound to Pilus Biogenesis Inhibitor, Pilicide 5D


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of E. Coli P Pilus Chaperone-Subunit Complex Papd-Paph Bound to Pilus Biogenesis Inhibitor, Pilicide 5D within 5.0Å range: probe atom residue distance (Å) B Occ B:Co1175 b:24.4 occ:0.50 NE2 B:HIS28 2.3 25.3 1.0 CE1 B:HIS28 3.2 24.2 1.0 CD2 B:HIS28 3.3 25.1 1.0 O B:ALA25 4.3 34.6 1.0 ND1 B:HIS28 4.3 24.6 1.0 CG B:HIS28 4.4 23.4 1.0

E.Chorell, J.S.Pinkner, G.Phan, S.Edvinsson, F.Buelens, H.Remaut, G.Waksman, S.J.Hultgren, F.Almqvist. Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity. J.Med.Chem. V. 53 5690 2010.
ISSN: ISSN 0022-2623
PubMed: 20586493
DOI: 10.1021/JM100470T