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Cobalt in PDB 3a9i: Crystal Structure of Homocitrate Synthase From Thermus Thermophilus Complexed with Lys

Enzymatic activity of Crystal Structure of Homocitrate Synthase From Thermus Thermophilus Complexed with Lys

All present enzymatic activity of Crystal Structure of Homocitrate Synthase From Thermus Thermophilus Complexed with Lys:
2.3.3.14;

Protein crystallography data

The structure of Crystal Structure of Homocitrate Synthase From Thermus Thermophilus Complexed with Lys, PDB code: 3a9i was solved by T.Okada, T.Tomita, T.Kuzuyama, M.Nishiyama, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.60 / 1.80
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 80.281, 96.025, 77.082, 90.00, 90.00, 90.00
R / Rfree (%) 17.1 / 21.3

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Crystal Structure of Homocitrate Synthase From Thermus Thermophilus Complexed with Lys (pdb code 3a9i). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the Crystal Structure of Homocitrate Synthase From Thermus Thermophilus Complexed with Lys, PDB code: 3a9i:

Cobalt binding site 1 out of 1 in 3a9i

Go back to Cobalt Binding Sites List in 3a9i
Cobalt binding site 1 out of 1 in the Crystal Structure of Homocitrate Synthase From Thermus Thermophilus Complexed with Lys


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of Homocitrate Synthase From Thermus Thermophilus Complexed with Lys within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co377

b:16.4
occ:1.00
NE2 A:HIS197 2.1 10.7 1.0
OE1 A:GLU13 2.1 12.2 1.0
N A:LYS378 2.1 20.3 1.0
O A:LYS378 2.2 17.0 1.0
NE2 A:HIS195 2.3 13.7 1.0
O A:HOH406 2.3 13.7 1.0
C A:LYS378 2.9 18.8 1.0
CD2 A:HIS197 3.0 9.1 1.0
CA A:LYS378 3.0 19.2 1.0
CD A:GLU13 3.1 12.6 1.0
CE1 A:HIS197 3.1 9.8 1.0
CE1 A:HIS195 3.1 7.1 1.0
CD2 A:HIS195 3.3 10.3 1.0
OE2 A:GLU13 3.5 12.8 1.0
CB A:LYS378 3.8 19.4 1.0
CG2 A:ILE231 4.1 9.8 1.0
OXT A:LYS378 4.1 19.5 1.0
CG A:HIS197 4.2 11.0 1.0
ND1 A:HIS197 4.2 10.2 1.0
ND1 A:HIS195 4.3 12.6 1.0
CG A:GLU13 4.4 9.9 1.0
CG A:HIS195 4.4 10.0 1.0
O A:HOH442 4.4 24.6 1.0
CB A:GLU13 4.8 10.3 1.0

Reference:

T.Okada, T.Tomita, A.P.Wulandari, T.Kuzuyama, M.Nishiyama. Mechanism of Substrate Recognition and Insight Into Feedback Inhibition of Homocitrate Synthase From Thermus Thermophilus J.Biol.Chem. V. 285 4195 2010.
ISSN: ISSN 0021-9258
PubMed: 19996101
DOI: 10.1074/JBC.M109.086330
Page generated: Tue Jul 30 15:45:23 2024

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