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Cobalt in PDB 3isq: Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase

Enzymatic activity of Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase

All present enzymatic activity of Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase:
1.13.11.27;

Protein crystallography data

The structure of Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase, PDB code: 3isq was solved by E.S.Pilka, N.Shafqat, R.Cocking, J.E.Bray, T.Krojer, A.C.W.Pike, F.Vondelft, W.W.Yue, C.H.Arrowsmith, J.Weigelt, A.Edwards, C.Bountra, U.Oppermann, K.L.Kavanagh, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.60 / 1.75
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 99.206, 99.206, 87.726, 90.00, 90.00, 120.00
R / Rfree (%) 14.4 / 17.4

Other elements in 3isq:

The structure of Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Sodium (Na) 1 atom

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase (pdb code 3isq). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase, PDB code: 3isq:

Cobalt binding site 1 out of 1 in 3isq

Go back to Cobalt Binding Sites List in 3isq
Cobalt binding site 1 out of 1 in the Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co901

b:12.8
occ:1.00
OE1 A:GLU349 1.9 11.4 1.0
NE2 A:HIS266 2.1 9.2 1.0
O A:HOH430 2.1 23.2 1.0
NE2 A:HIS183 2.1 10.7 1.0
O A:HOH480 2.3 21.5 1.0
CD A:GLU349 3.0 14.2 1.0
CE1 A:HIS266 3.0 10.4 1.0
CE1 A:HIS183 3.0 9.8 1.0
CD2 A:HIS183 3.1 10.7 1.0
CD2 A:HIS266 3.1 10.7 1.0
OE2 A:GLU349 3.4 14.8 1.0
CE1 A:PHE336 4.1 11.7 1.0
ND1 A:HIS266 4.2 10.4 1.0
ND1 A:HIS183 4.2 8.4 1.0
CG A:HIS266 4.2 9.8 1.0
CG A:HIS183 4.3 9.4 1.0
CG2 A:VAL185 4.3 11.4 1.0
NE2 A:GLN334 4.3 13.2 1.0
CG A:GLU349 4.3 11.4 1.0
CB A:ALA268 4.4 8.2 1.0
CB A:GLU349 4.5 9.5 1.0
CZ A:PHE336 4.6 10.4 1.0

Reference:

E.S.Pilka, N.Shafqat, R.Cocking, J.E.Bray, T.Krojer, A.C.W.Pike, F.Von Delft, W.W.Yue, C.H.Arrowsmith, J.Weigelt, A.Edwards, C.Bountra, U.Oppermann, K.L.Kavanagh. Crystal Structure of Human 4-Hydroxyphenylpyruvate Dioxygenase To Be Published.
Page generated: Sun Dec 13 10:40:54 2020

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