Cobalt in PDB 3ror: Crystal Structure of C105S Mutant of Mycobacterium Tuberculosis Methionine Aminopeptidase

All present enzymatic activity of Crystal Structure of C105S Mutant of Mycobacterium Tuberculosis Methionine Aminopeptidase:
3.4.11.18;

The structure of Crystal Structure of C105S Mutant of Mycobacterium Tuberculosis Methionine Aminopeptidase, PDB code: 3ror was solved by R.Reddi, C.Kishor, A.Addlagatta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.52 / 2.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	49.220, 48.660, 55.720, 90.00, 95.16, 90.00
R / Rfree (%)	21.1 / 27.4

The structure of Crystal Structure of C105S Mutant of Mycobacterium Tuberculosis Methionine Aminopeptidase also contains other interesting chemical elements:

Potassium

(K)

1 atom

The binding sites of Cobalt atom in the Crystal Structure of C105S Mutant of Mycobacterium Tuberculosis Methionine Aminopeptidase (pdb code 3ror). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Crystal Structure of C105S Mutant of Mycobacterium Tuberculosis Methionine Aminopeptidase, PDB code: 3ror:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Crystal Structure of C105S Mutant of Mycobacterium Tuberculosis Methionine Aminopeptidase


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of C105S Mutant of Mycobacterium Tuberculosis Methionine Aminopeptidase within 5.0Å range: probe atom residue distance (Å) B Occ A:Co290 b:12.4 occ:1.00 O A:HOH302 1.9 17.0 1.0 OE1 A:GLU269 2.0 8.1 1.0 OD1 A:ASP142 2.1 8.2 1.0 NE2 A:HIS205 2.1 14.9 1.0 OE2 A:GLU238 2.2 9.4 1.0 CD A:GLU238 3.0 14.1 1.0 CG A:ASP142 3.0 12.3 1.0 CD A:GLU269 3.0 15.8 1.0 CE1 A:HIS205 3.0 8.3 1.0 CD2 A:HIS205 3.1 10.5 1.0 OE1 A:GLU238 3.1 21.3 1.0 CO A:CO291 3.3 17.3 1.0 O A:HOH287 3.3 17.5 1.0 OE2 A:GLU269 3.3 13.0 1.0 OD2 A:ASP142 3.4 13.0 1.0 CG2 A:THR236 3.6 11.4 1.0 OG1 A:THR236 3.6 10.8 1.0 CB A:THR236 3.9 13.1 1.0 O A:HOH286 4.0 8.8 1.0 ND1 A:HIS205 4.1 6.2 1.0 CB A:ASP142 4.2 12.7 1.0 CG A:HIS205 4.2 13.9 1.0 CG A:GLU269 4.3 10.1 1.0 CG A:GLU238 4.3 8.9 1.0 CE1 A:HIS212 4.7 16.1 1.0 CB A:GLU238 4.8 12.2 1.0 CE1 A:PHE211 5.0 12.3 1.0

Cobalt binding site 2 out of 2 in the Crystal Structure of C105S Mutant of Mycobacterium Tuberculosis Methionine Aminopeptidase


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Crystal Structure of C105S Mutant of Mycobacterium Tuberculosis Methionine Aminopeptidase within 5.0Å range: probe atom residue distance (Å) B Occ A:Co291 b:17.3 occ:1.00 O A:HOH302 1.8 17.0 1.0 OE2 A:GLU269 2.1 13.0 1.0 OD2 A:ASP131 2.1 17.5 1.0 OD2 A:ASP142 2.1 13.0 1.0 O A:HOH286 2.2 8.8 1.0 OD1 A:ASP131 2.5 18.6 1.0 CG A:ASP131 2.6 16.1 1.0 CD A:GLU269 3.0 15.8 1.0 CG A:ASP142 3.1 12.3 1.0 CO A:CO290 3.3 12.4 1.0 OE1 A:GLU269 3.3 8.1 1.0 OD1 A:ASP142 3.4 8.2 1.0 O A:HOH287 3.8 17.5 1.0 OE1 A:GLU238 4.0 21.3 1.0 CB A:ASP131 4.1 14.2 1.0 N A:THR143 4.1 16.4 1.0 ND2 A:ASN144 4.1 11.1 1.0 OG1 A:THR133 4.1 14.2 1.0 CG A:GLU269 4.3 10.1 1.0 CB A:ASP142 4.5 12.7 1.0 CB A:ASN144 4.6 15.6 1.0 CD A:GLU238 4.6 14.1 1.0 C A:ASP142 4.7 14.6 1.0 C A:THR143 4.7 17.4 1.0 O A:THR143 4.7 18.7 1.0 OE2 A:GLU238 4.8 9.4 1.0 CA A:ASP131 4.8 15.6 1.0 O A:VAL132 4.8 20.6 1.0 N A:VAL132 4.8 17.8 1.0 CB A:GLU269 4.8 11.9 1.0 O A:HOH320 4.8 2.0 0.5 CA A:THR143 4.8 16.4 1.0 CA A:ASP142 4.9 13.9 1.0 C A:ASP131 4.9 16.3 1.0 CG A:ASN144 4.9 13.9 1.0

R.Reddi, C.Kishor, A.Addlagatta. Crystal Structure of C105S Mutant of Mycobacterium Tuberculosis Methionine Aminopeptidase To Be Published.