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Cobalt in PDB 3tcy: Crystallographic Structure of Phenylalanine Hydroxylase From Chromobacterium Violaceum (Cpah) Bound to Phenylalanine in A Site Distal to the Active Site

Enzymatic activity of Crystallographic Structure of Phenylalanine Hydroxylase From Chromobacterium Violaceum (Cpah) Bound to Phenylalanine in A Site Distal to the Active Site

All present enzymatic activity of Crystallographic Structure of Phenylalanine Hydroxylase From Chromobacterium Violaceum (Cpah) Bound to Phenylalanine in A Site Distal to the Active Site:
1.14.16.1;

Protein crystallography data

The structure of Crystallographic Structure of Phenylalanine Hydroxylase From Chromobacterium Violaceum (Cpah) Bound to Phenylalanine in A Site Distal to the Active Site, PDB code: 3tcy was solved by J.A.Ronau, M.M.Abu-Omar, C.Das, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.25 / 1.55
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 36.674, 38.281, 47.736, 76.65, 73.03, 85.69
R / Rfree (%) 16.3 / 20.7

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Crystallographic Structure of Phenylalanine Hydroxylase From Chromobacterium Violaceum (Cpah) Bound to Phenylalanine in A Site Distal to the Active Site (pdb code 3tcy). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Crystallographic Structure of Phenylalanine Hydroxylase From Chromobacterium Violaceum (Cpah) Bound to Phenylalanine in A Site Distal to the Active Site, PDB code: 3tcy:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in 3tcy

Go back to Cobalt Binding Sites List in 3tcy
Cobalt binding site 1 out of 2 in the Crystallographic Structure of Phenylalanine Hydroxylase From Chromobacterium Violaceum (Cpah) Bound to Phenylalanine in A Site Distal to the Active Site


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystallographic Structure of Phenylalanine Hydroxylase From Chromobacterium Violaceum (Cpah) Bound to Phenylalanine in A Site Distal to the Active Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co298

b:12.0
occ:1.00
 NE2 A:HIS138 2.0 9.1 1.0
OE2 A:GLU184 2.1 9.5 1.0
O A:HOH484 2.1 12.2 1.0
NE2 A:HIS143 2.1 8.3 1.0
O A:HOH457 2.2 14.0 1.0
OE1 A:GLU184 2.2 10.1 1.0
CD A:GLU184 2.5 9.4 1.0
CE1 A:HIS138 2.9 10.0 1.0
CD2 A:HIS138 3.1 8.3 1.0
CE1 A:HIS143 3.1 8.9 1.0
CD2 A:HIS143 3.1 9.8 1.0
O A:HOH325 3.8 16.1 1.0
CG A:GLU184 4.0 10.2 1.0
ND1 A:HIS138 4.1 10.1 1.0
CG A:HIS138 4.2 8.2 1.0
OD1 A:ASP139 4.2 16.2 1.0
ND1 A:HIS143 4.2 10.3 1.0
O A:HOH486 4.2 33.3 1.0
CG A:HIS143 4.3 9.5 1.0
O A:HOH512 4.3 42.0 1.0
O A:HOH407 4.3 22.3 1.0
O A:HOH475 4.3 35.1 1.0
CB A:ALA199 4.6 8.7 1.0
CB A:GLU184 4.9 8.7 1.0
O A:HOH383 5.0 30.0 1.0

Cobalt binding site 2 out of 2 in 3tcy

Go back to Cobalt Binding Sites List in 3tcy
Cobalt binding site 2 out of 2 in the Crystallographic Structure of Phenylalanine Hydroxylase From Chromobacterium Violaceum (Cpah) Bound to Phenylalanine in A Site Distal to the Active Site


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Crystallographic Structure of Phenylalanine Hydroxylase From Chromobacterium Violaceum (Cpah) Bound to Phenylalanine in A Site Distal to the Active Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co299

b:25.2
occ:1.00
 NE2 A:HIS22 2.0 16.9 1.0
O A:HOH516 2.5 43.1 1.0
CE1 A:HIS22 3.0 17.0 1.0
CD2 A:HIS22 3.1 17.7 1.0
O A:HOH515 3.5 45.9 1.0
ND1 A:HIS22 4.1 16.4 1.0
CG A:HIS22 4.2 16.3 1.0
O A:HOH464 4.6 34.2 1.0

Reference:

J.A.Ronau, L.N.Paul, J.E.Fuchs, I.R.Corn, K.T.Wagner, K.R.Liedl, M.M.Abu-Omar, C.Das. An Additional Substrate Binding Site in A Bacterial Phenylalanine Hydroxylase. Eur.Biophys.J. V. 42 691 2013.
ISSN: ISSN 0175-7571
PubMed: 23860686
DOI: 10.1007/S00249-013-0919-8
Page generated: Tue Jul 30 16:35:37 2024

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