Cobalt in PDB 3uc3: The Crystal Structure of SNF1-Related Kinase 2.3

All present enzymatic activity of The Crystal Structure of SNF1-Related Kinase 2.3:
2.7.11.1;

The structure of The Crystal Structure of SNF1-Related Kinase 2.3, PDB code: 3uc3 was solved by X.E.Zhou, L.-M.Ng, F.-F.Soon, A.Kovach, K.M.Suino-Powell, J.Li, K.Melcher, H.E.Xu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.48 / 1.90
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	75.411, 75.411, 116.434, 90.00, 90.00, 120.00
R / Rfree (%)	21.2 / 23

The binding sites of Cobalt atom in the The Crystal Structure of SNF1-Related Kinase 2.3 (pdb code 3uc3). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 3 binding sites of Cobalt where determined in the The Crystal Structure of SNF1-Related Kinase 2.3, PDB code: 3uc3:
Jump to Cobalt binding site number: 1; 2; 3;

Cobalt binding site 1 out of 3 in the The Crystal Structure of SNF1-Related Kinase 2.3


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of The Crystal Structure of SNF1-Related Kinase 2.3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co362 b:34.6 occ:1.00 SG A:CYS132 2.1 20.6 1.0 CB A:CYS132 3.1 17.5 1.0 CG A:ARG140 3.7 21.8 1.0 NE A:ARG140 4.2 24.9 1.0 CG2 A:ILE137 4.3 17.9 1.0 CD A:ARG140 4.3 23.1 1.0 CA A:CYS132 4.5 17.2 1.0 CD1 A:LEU73 4.6 31.6 1.0 CB A:ARG140 4.6 21.4 1.0 CD1 A:ILE78 4.8 21.4 1.0 O A:GLY128 4.9 16.5 1.0 CG2 A:ILE159 5.0 24.3 1.0

Cobalt binding site 2 out of 3 in the The Crystal Structure of SNF1-Related Kinase 2.3


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of The Crystal Structure of SNF1-Related Kinase 2.3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co363 b:55.1 occ:1.00 SG A:CYS160 2.1 27.7 1.0 CB A:CYS160 3.0 25.1 1.0 O A:CYS160 3.3 25.1 1.0 C A:CYS160 3.5 25.9 1.0 CA A:CYS160 3.7 24.9 1.0 N A:PHE162 4.1 30.0 1.0 N A:ASP161 4.2 27.6 1.0 O A:PHE162 4.3 31.4 1.0 O A:HOH492 4.4 53.6 1.0 CD1 A:PHE162 4.6 28.1 1.0 CB A:PHE162 4.8 29.8 1.0 CA A:ASP161 4.9 29.6 1.0 CD2 A:PHE33 4.9 36.0 1.0 C A:ASP161 4.9 29.8 1.0 CA A:PHE162 4.9 30.2 1.0

Cobalt binding site 3 out of 3 in the The Crystal Structure of SNF1-Related Kinase 2.3


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 3 of The Crystal Structure of SNF1-Related Kinase 2.3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co364 b:21.8 occ:1.00 SG A:CYS138 2.2 18.2 1.0 CB A:CYS138 3.1 18.6 1.0 O A:GLN136 3.3 18.0 1.0 N A:CYS138 3.4 18.9 1.0 C A:GLN136 3.5 17.5 1.0 C A:ILE137 3.7 18.5 1.0 CA A:CYS138 3.8 19.1 1.0 N A:ILE137 3.8 17.6 1.0 CA A:ILE137 4.0 18.1 1.0 CA A:GLN136 4.1 17.6 1.0 O A:HOH460 4.2 30.3 1.0 CE A:LYS197 4.2 14.7 1.0 O A:ILE137 4.3 18.7 1.0 O A:HOH369 4.6 22.5 1.0 C A:CYS138 4.6 20.0 1.0 CG A:LYS197 4.6 13.9 1.0 O A:HOH454 4.7 38.8 1.0 CB A:GLN136 4.7 17.3 1.0 O A:CYS138 4.9 20.2 1.0

L.M.Ng, F.F.Soon, X.E.Zhou, G.M.West, A.Kovach, K.M.Suino-Powell, M.J.Chalmers, J.Li, E.L.Yong, J.K.Zhu, P.R.Griffin, K.Melcher, H.E.Xu. Structural Basis For Basal Activity and Autoactivation of Abscisic Acid (Aba) Signaling SNRK2 Kinases. Proc.Natl.Acad.Sci.Usa V. 108 21259 2011.
ISSN: ISSN 0027-8424
PubMed: 22160701
DOI: 10.1073/PNAS.1118651109