Cobalt in PDB 3w7j: Structure of Trypanosoma Cruzi Dihydroorotate Dehydrogenase in Complex with Mii-6-040

All present enzymatic activity of Structure of Trypanosoma Cruzi Dihydroorotate Dehydrogenase in Complex with Mii-6-040:
1.3.98.1;

The structure of Structure of Trypanosoma Cruzi Dihydroorotate Dehydrogenase in Complex with Mii-6-040, PDB code: 3w7j was solved by D.K.Inaoka, M.Iida, T.Tabuchi, N.Lee, S.Hashimoto, S.Matsuoka, T.Kuranaga, T.Shiba, K.Sakamoto, S.Suzuki, E.O.Balogun, T.Nara, T.Aoki, M.Inoue, T.Honma, A.Tanaka, S.Harada, K.Kita, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.26 / 1.58
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	67.999, 71.693, 129.418, 90.00, 90.00, 90.00
R / Rfree (%)	14.7 / 18.2

The binding sites of Cobalt atom in the Structure of Trypanosoma Cruzi Dihydroorotate Dehydrogenase in Complex with Mii-6-040 (pdb code 3w7j). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Structure of Trypanosoma Cruzi Dihydroorotate Dehydrogenase in Complex with Mii-6-040, PDB code: 3w7j:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Structure of Trypanosoma Cruzi Dihydroorotate Dehydrogenase in Complex with Mii-6-040


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Structure of Trypanosoma Cruzi Dihydroorotate Dehydrogenase in Complex with Mii-6-040 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co412 b:8.6 occ:1.00 CO A:NCO412 0.0 8.6 1.0 N4 A:NCO412 2.0 8.1 1.0 N1 A:NCO412 2.0 9.0 1.0 N2 A:NCO412 2.1 8.7 1.0 N5 A:NCO412 2.1 9.5 1.0 N6 A:NCO412 2.1 8.3 1.0 N3 A:NCO412 2.1 9.6 1.0 O A:GLN275 3.8 5.7 1.0 O A:HOH606 4.0 24.3 1.0 O A:GLU276 4.2 6.9 1.0 O A:HOH752 4.3 25.4 1.0 O A:HOH722 4.3 23.5 1.0 O A:HOH541 4.4 14.3 1.0 O A:HOH754 4.4 23.1 1.0 O A:HOH711 4.5 29.2 1.0 O A:HOH664 4.6 32.5 1.0 C A:GLU276 4.8 5.5 1.0

Cobalt binding site 2 out of 2 in the Structure of Trypanosoma Cruzi Dihydroorotate Dehydrogenase in Complex with Mii-6-040


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Structure of Trypanosoma Cruzi Dihydroorotate Dehydrogenase in Complex with Mii-6-040 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co413 b:33.5 occ:1.00 CO A:NCO413 0.0 33.5 1.0 N4 A:NCO413 2.0 33.7 1.0 N3 A:NCO413 2.0 31.9 1.0 N5 A:NCO413 2.0 34.2 1.0 N2 A:NCO413 2.0 30.6 1.0 N6 A:NCO413 2.0 31.2 1.0 N1 A:NCO413 2.0 32.0 1.0 OD2 A:ASP203 4.4 14.3 1.0 OD1 A:ASP203 4.4 14.2 1.0 CG A:ASP203 4.6 12.2 1.0

D.K.Inaoka, M.Iida, T.Tabuchi, N.Lee, S.Hashimoto, S.Matsuoka, T.Kuranaga, T.Shiba, K.Sakamoto, S.Suzuki, E.O.Balogun, T.Nara, T.Aoki, M.Inoue, T.Honma, A.Tanaka, S.Harada, K.Kita. Structure of Trypanosoma Cruzi Dihydroorotate Dehydrogenase in Complex with Mii-6-040 To Be Published.