Cobalt in PDB 4as7: EG5 Complex 1

The structure of EG5 Complex 1, PDB code: 4as7 was solved by S.K.Talapatra, F.Kozielski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.936 / 2.40
Space group	P 65
Cell size a, b, c (Å), α, β, γ (°)	81.070, 81.070, 123.961, 90.00, 90.00, 120.00
R / Rfree (%)	15.89 / 21.24

The structure of EG5 Complex 1 also contains other interesting chemical elements:

Cadmium	(Cd)	6 atoms
Chlorine	(Cl)	5 atoms

The binding sites of Cobalt atom in the EG5 Complex 1 (pdb code 4as7). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the EG5 Complex 1, PDB code: 4as7:

Cobalt binding site 1 out of 1 in the EG5 Complex 1


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of EG5 Complex 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co1368 b:61.6 occ:1.00 N A:ALA74 3.6 26.1 1.0 O A:HOH2052 3.7 31.3 1.0 CA A:GLY73 3.8 20.8 1.0 SG A:CYS43 4.0 27.0 1.0 CB A:CYS43 4.0 25.3 1.0 N A:CYS43 4.1 23.3 1.0 O A:HOH2024 4.2 38.8 1.0 C A:GLY73 4.3 23.2 1.0 CB A:ALA74 4.4 27.9 1.0 O A:VAL41 4.5 27.6 1.0 CA A:ALA74 4.6 26.5 1.0 CA A:CYS43 4.6 26.3 1.0 O A:HOH2051 4.9 32.5 1.0 O A:CYS43 4.9 26.9 1.0 C A:GLU42 5.0 27.1 1.0

S.K.Talapatra, N.G.Anthony, S.P.Mackay, F.Kozielski. The Mitotic Kinesin EG5 Overcomes Inhibition to the Phase I/II Clinical Candidate SB743921 By An Allosteric Resistance Mechanism. J.Med.Chem. V. 56 6317 2013.
ISSN: ISSN 0022-2623
PubMed: 23875972
DOI: 10.1021/JM4006274