Cobalt in PDB 4ekd: Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C)

All present enzymatic activity of Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C):
3.6.5.1;

The structure of Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C), PDB code: 4ekd was solved by J.J.G.Tesmer, M.R.Nance, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.98 / 2.71
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	60.248, 60.248, 345.569, 90.00, 90.00, 90.00
R / Rfree (%)	19 / 25.2

The structure of Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C) also contains other interesting chemical elements:

Fluorine	(F)	4 atoms
Magnesium	(Mg)	1 atom
Aluminium	(Al)	1 atom
Chlorine	(Cl)	2 atoms

The binding sites of Cobalt atom in the Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C) (pdb code 4ekd). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C), PDB code: 4ekd:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C)


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C) within 5.0Å range: probe atom residue distance (Å) B Occ A:Co403 b:95.1 occ:1.00 NE2 A:HIS105 1.8 0.6 1.0 CL A:CL404 2.5 0.7 1.0 CL A:CL405 2.5 96.6 1.0 NE2 A:HIS109 2.5 0.1 1.0 CD2 A:HIS105 2.7 99.4 1.0 CE1 A:HIS105 2.9 0.7 1.0 CD2 A:HIS109 3.2 0.6 1.0 CE1 A:HIS109 3.7 0.3 1.0 CG A:HIS105 3.9 0.1 1.0 ND1 A:HIS105 4.0 0.1 1.0 CG A:HIS109 4.5 0.1 1.0 ND1 A:HIS109 4.7 0.9 1.0

Cobalt binding site 2 out of 2 in the Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C)


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C) within 5.0Å range: probe atom residue distance (Å) B Occ A:Co406 b:0.2 occ:1.00 OD1 A:ASP321 2.1 0.6 1.0 OD1 A:ASP319 2.1 0.0 1.0 CG A:ASP319 2.9 0.1 1.0 CG A:ASP321 2.9 0.1 1.0 OD2 A:ASP319 3.0 0.1 1.0 OD2 A:ASP321 3.1 0.4 1.0 CB A:ASP321 4.4 0.3 1.0 CB A:ASP319 4.4 0.3 1.0 N A:ASP321 4.8 0.3 1.0 CA A:ASP319 4.9 0.7 1.0

M.R.Nance, B.Kreutz, V.M.Tesmer, R.Sterne-Marr, T.Kozasa, J.J.Tesmer. Structural and Functional Analysis of the Regulator of G Protein Signaling 2-G Alpha Q Complex. Structure V. 21 438 2013.
ISSN: ISSN 0969-2126
PubMed: 23434405
DOI: 10.1016/J.STR.2012.12.016