Cobalt in PDB 4g87: Crystal Structure of Glmu From Mycobacterium Tuberculosis Snapshot 1

All present enzymatic activity of Crystal Structure of Glmu From Mycobacterium Tuberculosis Snapshot 1:
2.3.1.157; 2.7.7.23;

The structure of Crystal Structure of Glmu From Mycobacterium Tuberculosis Snapshot 1, PDB code: 4g87 was solved by P.A.Jagtap, S.K.Verma, B.Prakash, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	18.84 / 2.03
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	77.000, 77.000, 276.730, 90.00, 90.00, 120.00
R / Rfree (%)	17.8 / 23.5

The structure of Crystal Structure of Glmu From Mycobacterium Tuberculosis Snapshot 1 also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Cobalt atom in the Crystal Structure of Glmu From Mycobacterium Tuberculosis Snapshot 1 (pdb code 4g87). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Crystal Structure of Glmu From Mycobacterium Tuberculosis Snapshot 1, PDB code: 4g87:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Crystal Structure of Glmu From Mycobacterium Tuberculosis Snapshot 1


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of Glmu From Mycobacterium Tuberculosis Snapshot 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co502 b:47.0 occ:1.00 O2B A:UD1505 2.0 21.1 1.0 O2A A:UD1505 2.0 29.3 1.0 OD2 A:ASP114 2.2 21.5 1.0 OD1 A:ASN239 2.3 16.5 1.0 O A:HOH684 2.3 18.9 1.0 O A:HOH635 2.3 18.7 1.0 CG A:ASP114 3.1 19.6 1.0 CG A:ASN239 3.2 16.0 1.0 PB A:UD1505 3.2 20.6 1.0 PA A:UD1505 3.2 28.7 1.0 O3A A:UD1505 3.3 21.0 1.0 OD1 A:ASP114 3.3 21.8 1.0 ND2 A:ASN239 3.4 16.2 1.0 NZ A:LYS26 3.6 24.1 1.0 O6' A:UD1505 3.8 20.3 1.0 O5B A:UD1505 4.2 24.6 1.0 O5' A:UD1505 4.2 19.4 1.0 O1' A:UD1505 4.3 20.9 1.0 O1B A:UD1505 4.3 24.7 1.0 O1A A:UD1505 4.3 27.7 1.0 C5B A:UD1505 4.4 20.4 1.0 O A:VAL238 4.4 18.1 1.0 CB A:ASP114 4.5 20.7 1.0 O2 A:POP506 4.5 27.5 0.8 CB A:ASN239 4.5 17.1 1.0 C1' A:UD1505 4.6 22.0 1.0 O A:HOH997 4.6 19.2 1.0 C A:VAL238 4.7 18.7 1.0 CE A:LYS26 4.7 23.5 1.0 O3B A:UD1505 4.8 18.6 1.0 CA A:ASN239 4.8 18.0 1.0 NH2 A:ARG19 4.8 20.9 1.0 C5' A:UD1505 4.8 20.1 1.0 C3B A:UD1505 4.9 19.9 1.0 N A:ASN239 4.9 17.0 1.0 N A:VAL238 4.9 18.1 1.0 C6' A:UD1505 5.0 14.5 1.0

Cobalt binding site 2 out of 2 in the Crystal Structure of Glmu From Mycobacterium Tuberculosis Snapshot 1


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Crystal Structure of Glmu From Mycobacterium Tuberculosis Snapshot 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co503 b:33.1 occ:0.33 OD2 A:ASP417 2.1 22.7 1.0 CG A:ASP417 2.9 21.8 1.0 OD1 A:ASP417 3.1 20.7 1.0 O A:HOH733 3.5 21.9 1.0 MG A:MG501 3.7 37.2 1.0 CB A:ASP417 4.3 18.4 1.0 O A:ASP417 4.7 20.5 1.0 O A:HOH890 4.9 29.0 1.0

P.K.A.Jagtap, S.K.Verma, N.Vithani, V.S.Bais, B.Prakash. Crystal Structures Identify An Atypical Two-Metal-Ion Mechanism For Uridyltransfer in Glmu: Its Significance to Sugar Nucleotidyl Transferases J.Mol.Biol. V. 425 1745 2013.
ISSN: ISSN 0022-2836
PubMed: 23485416
DOI: 10.1016/J.JMB.2013.02.019