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Atomistry » Cobalt » PDB 4fe5-4j0b » 4iku | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Cobalt » PDB 4fe5-4j0b » 4iku » |
Cobalt in PDB 4iku: Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with 2-((5-Chloro-6-Methyl-2- (Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)-3-PhenylpropanamideEnzymatic activity of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with 2-((5-Chloro-6-Methyl-2- (Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)-3-Phenylpropanamide
All present enzymatic activity of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with 2-((5-Chloro-6-Methyl-2- (Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)-3-Phenylpropanamide:
3.4.11.18; Protein crystallography data
The structure of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with 2-((5-Chloro-6-Methyl-2- (Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)-3-Phenylpropanamide, PDB code: 4iku
was solved by
A.Addlagatta,
C.Kishor,
T.Arya,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4iku:
The structure of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with 2-((5-Chloro-6-Methyl-2- (Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)-3-Phenylpropanamide also contains other interesting chemical elements:
Cobalt Binding Sites:
The binding sites of Cobalt atom in the Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with 2-((5-Chloro-6-Methyl-2- (Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)-3-Phenylpropanamide
(pdb code 4iku). This binding sites where shown within
5.0 Angstroms radius around Cobalt atom.
In total 3 binding sites of Cobalt where determined in the Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with 2-((5-Chloro-6-Methyl-2- (Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)-3-Phenylpropanamide, PDB code: 4iku: Jump to Cobalt binding site number: 1; 2; 3; Cobalt binding site 1 out of 3 in 4ikuGo back to![]() ![]()
Cobalt binding site 1 out
of 3 in the Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with 2-((5-Chloro-6-Methyl-2- (Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)-3-Phenylpropanamide
![]() Mono view ![]() Stereo pair view
Cobalt binding site 2 out of 3 in 4ikuGo back to![]() ![]()
Cobalt binding site 2 out
of 3 in the Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with 2-((5-Chloro-6-Methyl-2- (Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)-3-Phenylpropanamide
![]() Mono view ![]() Stereo pair view
Cobalt binding site 3 out of 3 in 4ikuGo back to![]() ![]()
Cobalt binding site 3 out
of 3 in the Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with 2-((5-Chloro-6-Methyl-2- (Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)-3-Phenylpropanamide
![]() Mono view ![]() Stereo pair view
Reference:
C.Kishor,
T.Arya,
R.Reddi,
X.Chen,
V.Saddanapu,
A.K.Marapaka,
R.Gumpena,
D.Ma,
J.O.Liu,
A.Addlagatta.
Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors Against Type I Methionine Aminopeptidases J.Med.Chem. V. 56 5295 2013.
Page generated: Tue Jul 30 17:11:33 2024
ISSN: ISSN 0022-2623 PubMed: 23767698 DOI: 10.1021/JM400395P |
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