Cobalt in PDB 4iyn: Structure of Mitochondrial HSP90 (TRAP1) with Adp-ALF4-

The structure of Structure of Mitochondrial HSP90 (TRAP1) with Adp-ALF4-, PDB code: 4iyn was solved by J.R.Partridge, L.A.Lavery, D.A.Agard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.81 / 2.31
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	178.896, 96.597, 125.901, 90.00, 134.26, 90.00
R / Rfree (%)	19.1 / 23.1

The structure of Structure of Mitochondrial HSP90 (TRAP1) with Adp-ALF4- also contains other interesting chemical elements:

Fluorine	(F)	8 atoms
Magnesium	(Mg)	2 atoms
Aluminium	(Al)	2 atoms

The binding sites of Cobalt atom in the Structure of Mitochondrial HSP90 (TRAP1) with Adp-ALF4- (pdb code 4iyn). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 4 binding sites of Cobalt where determined in the Structure of Mitochondrial HSP90 (TRAP1) with Adp-ALF4-, PDB code: 4iyn:
Jump to Cobalt binding site number: 1; 2; 3; 4;

Cobalt binding site 1 out of 4 in the Structure of Mitochondrial HSP90 (TRAP1) with Adp-ALF4-


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Structure of Mitochondrial HSP90 (TRAP1) with Adp-ALF4- within 5.0Å range: probe atom residue distance (Å) B Occ A:Co801 b:0.2 occ:0.86 OD1 A:ASN95 3.7 0.7 1.0 OD1 A:ASP92 4.2 0.2 1.0 OD2 A:ASP92 4.3 0.1 1.0 O A:GLU94 4.3 0.7 1.0 CG A:ASP92 4.6 0.2 1.0 CG A:ASN95 4.9 0.0 1.0

Cobalt binding site 2 out of 4 in the Structure of Mitochondrial HSP90 (TRAP1) with Adp-ALF4-


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Structure of Mitochondrial HSP90 (TRAP1) with Adp-ALF4- within 5.0Å range: probe atom residue distance (Å) B Occ A:Co805 b:0.2 occ:0.88 OD1 A:ASN204 2.2 87.3 1.0 CG A:ASN204 3.3 88.1 1.0 O A:LEU202 3.4 50.1 1.0 ND2 A:ASN204 3.7 89.7 1.0 O A:ASP200 4.1 54.8 1.0 N A:ASN204 4.6 87.2 1.0 CB A:ASN204 4.6 87.7 1.0 C A:LEU202 4.6 50.0 1.0 CA A:ASN204 4.9 86.4 1.0

Cobalt binding site 3 out of 4 in the Structure of Mitochondrial HSP90 (TRAP1) with Adp-ALF4-


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 3 of Structure of Mitochondrial HSP90 (TRAP1) with Adp-ALF4- within 5.0Å range: probe atom residue distance (Å) B Occ B:Co801 b:96.0 occ:1.00 O B:MET505 3.6 59.9 1.0 O B:SER503 3.7 65.9 1.0 C B:SER503 4.8 62.2 1.0 C B:MET505 4.8 59.0 1.0

Cobalt binding site 4 out of 4 in the Structure of Mitochondrial HSP90 (TRAP1) with Adp-ALF4-


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 4 of Structure of Mitochondrial HSP90 (TRAP1) with Adp-ALF4- within 5.0Å range: probe atom residue distance (Å) B Occ B:Co802 b:0.2 occ:0.77 OD1 B:ASP92 3.3 0.6 1.0 O B:GLU94 4.2 76.1 1.0 CG B:ASP92 4.2 0.6 1.0 OD2 B:ASP92 4.3 0.4 1.0 OD1 B:ASN95 4.9 81.0 1.0

L.A.Lavery, J.R.Partridge, T.A.Ramelot, D.Elnatan, M.A.Kennedy, D.A.Agard. Structural Asymmetry in the Closed State of Mitochondrial HSP90 (TRAP1) Supports A Two-Step Atp Hydrolysis Mechanism. Mol.Cell V. 53 330 2014.
ISSN: ISSN 1097-2765
PubMed: 24462206
DOI: 10.1016/J.MOLCEL.2013.12.023