Cobalt in PDB 4j0b: Structure of Mitochondrial HSP90 (TRAP1) with Adp-BEF3

The structure of Structure of Mitochondrial HSP90 (TRAP1) with Adp-BEF3, PDB code: 4j0b was solved by J.R.Partridge, L.A.Lavery, D.A.Agard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.82 / 2.35
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	177.779, 96.566, 124.977, 90.00, 134.29, 90.00
R / Rfree (%)	20.5 / 24.8

The structure of Structure of Mitochondrial HSP90 (TRAP1) with Adp-BEF3 also contains other interesting chemical elements:

Fluorine	(F)	6 atoms
Magnesium	(Mg)	2 atoms

The binding sites of Cobalt atom in the Structure of Mitochondrial HSP90 (TRAP1) with Adp-BEF3 (pdb code 4j0b). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 4 binding sites of Cobalt where determined in the Structure of Mitochondrial HSP90 (TRAP1) with Adp-BEF3, PDB code: 4j0b:
Jump to Cobalt binding site number: 1; 2; 3; 4;

Cobalt binding site 1 out of 4 in the Structure of Mitochondrial HSP90 (TRAP1) with Adp-BEF3


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Structure of Mitochondrial HSP90 (TRAP1) with Adp-BEF3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co801 b:0.2 occ:0.84 OD1 A:ASN95 3.4 0.2 1.0 OD2 A:ASP92 3.8 0.4 1.0 OD1 A:ASP92 3.8 0.5 1.0 O A:GLU94 4.2 97.3 1.0 CG A:ASP92 4.2 0.8 1.0 CG A:ASN95 4.5 0.4 1.0

Cobalt binding site 2 out of 4 in the Structure of Mitochondrial HSP90 (TRAP1) with Adp-BEF3


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Structure of Mitochondrial HSP90 (TRAP1) with Adp-BEF3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co802 b:0.3 occ:0.88 OD1 A:ASN204 2.2 0.9 1.0 CG A:ASN204 3.2 0.2 1.0 O A:LEU202 3.5 68.7 1.0 ND2 A:ASN204 3.7 0.1 1.0 O A:ASP200 4.3 74.2 1.0 CB A:ASN204 4.6 0.2 1.0 N A:ASN204 4.6 0.3 1.0 C A:LEU202 4.8 69.3 1.0 CA A:ASN204 4.9 0.8 1.0 C A:ASP200 5.0 74.0 1.0

Cobalt binding site 3 out of 4 in the Structure of Mitochondrial HSP90 (TRAP1) with Adp-BEF3


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 3 of Structure of Mitochondrial HSP90 (TRAP1) with Adp-BEF3 within 5.0Å range: probe atom residue distance (Å) B Occ B:Co801 b:94.0 occ:1.00 O B:SER503 3.7 80.1 1.0 O B:MET505 4.3 69.3 1.0 C B:SER503 4.7 79.0 1.0 O B:LYS506 4.8 92.8 1.0

Cobalt binding site 4 out of 4 in the Structure of Mitochondrial HSP90 (TRAP1) with Adp-BEF3


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 4 of Structure of Mitochondrial HSP90 (TRAP1) with Adp-BEF3 within 5.0Å range: probe atom residue distance (Å) B Occ B:Co802 b:0.2 occ:0.82 OD1 B:ASP92 3.5 0.5 1.0 O B:GLU94 4.1 83.1 1.0 OD2 B:ASP92 4.3 0.7 1.0 CG B:ASP92 4.4 0.1 1.0 OD1 B:ASN95 4.5 86.5 1.0

L.A.Lavery, J.R.Partridge, T.A.Ramelot, D.Elnatan, M.A.Kennedy, D.A.Agard. Structural Asymmetry in the Closed State of Mitochondrial HSP90 (TRAP1) Supports A Two-Step Atp Hydrolysis Mechanism. Mol.Cell V. 53 330 2014.
ISSN: ISSN 1097-2765
PubMed: 24462206
DOI: 10.1016/J.MOLCEL.2013.12.023