Cobalt in PDB 4pw8: Human Tryptophan 2,3-Dioxygenase

All present enzymatic activity of Human Tryptophan 2,3-Dioxygenase:
1.13.11.11;

The structure of Human Tryptophan 2,3-Dioxygenase, PDB code: 4pw8 was solved by B.Meng, D.Wu, J.H.Gu, S.Y.Ouyang, W.Ding, Z.J.Liu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.73 / 2.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	134.334, 156.922, 160.330, 90.00, 90.00, 90.00
R / Rfree (%)	20.4 / 22.2

The binding sites of Cobalt atom in the Human Tryptophan 2,3-Dioxygenase (pdb code 4pw8). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the Human Tryptophan 2,3-Dioxygenase, PDB code: 4pw8:

Cobalt binding site 1 out of 1 in the Human Tryptophan 2,3-Dioxygenase


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Human Tryptophan 2,3-Dioxygenase within 5.0Å range: probe atom residue distance (Å) B Occ H:Co401 b:57.6 occ:1.00 OE2 H:GLU203 3.5 84.6 1.0 OE2 A:GLU203 3.8 68.8 1.0 O H:GLN197 4.2 47.8 1.0 O A:GLN197 4.3 59.1 1.0 OE1 A:GLU203 4.4 47.6 1.0 O A:GLU196 4.4 56.5 1.0 CD H:GLU203 4.5 55.1 1.0 O H:GLU196 4.5 50.6 1.0 CD A:GLU203 4.5 48.5 1.0 OE1 H:GLU203 4.6 50.9 1.0 O A:GLU198 4.7 45.5 1.0 O H:GLU198 5.0 37.5 1.0

B.Meng, D.Wu, J.H.Gu, S.Y.Ouyang, W.Ding, Z.J.Liu. Structural and Functional Analyses of Human Tryptophan 2,3-Dioxygenase Proteins 2014.
ISSN: ESSN 1097-0134