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Cobalt in PDB 4xyj: Crystal Structure of Human Phosphofructokinase-1 in Complex with Atp and Mg, Northeast Structural Genomics Consortium Target HR9275

Enzymatic activity of Crystal Structure of Human Phosphofructokinase-1 in Complex with Atp and Mg, Northeast Structural Genomics Consortium Target HR9275

All present enzymatic activity of Crystal Structure of Human Phosphofructokinase-1 in Complex with Atp and Mg, Northeast Structural Genomics Consortium Target HR9275:
2.7.1.11;

Protein crystallography data

The structure of Crystal Structure of Human Phosphofructokinase-1 in Complex with Atp and Mg, Northeast Structural Genomics Consortium Target HR9275, PDB code: 4xyj was solved by F.Forouhar, B.A.Webb, F.-E.Szu, J.Seetharaman, D.L.Barber, L.Tong, Northeast Structural Genomics Consortium (Nesg), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.69 / 3.10
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 137.199, 159.329, 170.533, 90.00, 104.20, 90.00
R / Rfree (%) 22.1 / 24.6

Other elements in 4xyj:

The structure of Crystal Structure of Human Phosphofructokinase-1 in Complex with Atp and Mg, Northeast Structural Genomics Consortium Target HR9275 also contains other interesting chemical elements:

Magnesium (Mg) 15 atoms

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Crystal Structure of Human Phosphofructokinase-1 in Complex with Atp and Mg, Northeast Structural Genomics Consortium Target HR9275 (pdb code 4xyj). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Crystal Structure of Human Phosphofructokinase-1 in Complex with Atp and Mg, Northeast Structural Genomics Consortium Target HR9275, PDB code: 4xyj:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in 4xyj

Go back to Cobalt Binding Sites List in 4xyj
Cobalt binding site 1 out of 2 in the Crystal Structure of Human Phosphofructokinase-1 in Complex with Atp and Mg, Northeast Structural Genomics Consortium Target HR9275


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of Human Phosphofructokinase-1 in Complex with Atp and Mg, Northeast Structural Genomics Consortium Target HR9275 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Co806

b:48.0
occ:1.00
OD1 B:ASP378 2.3 77.2 1.0
OD2 B:ASP378 2.5 76.0 1.0
O B:HOH907 2.5 16.9 1.0
CG B:ASP378 2.7 76.7 1.0
CB B:ASP378 4.2 76.8 1.0
NH2 B:ARG381 4.6 86.4 1.0
NE B:ARG375 4.9 71.7 1.0

Cobalt binding site 2 out of 2 in 4xyj

Go back to Cobalt Binding Sites List in 4xyj
Cobalt binding site 2 out of 2 in the Crystal Structure of Human Phosphofructokinase-1 in Complex with Atp and Mg, Northeast Structural Genomics Consortium Target HR9275


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Crystal Structure of Human Phosphofructokinase-1 in Complex with Atp and Mg, Northeast Structural Genomics Consortium Target HR9275 within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Co806

b:71.7
occ:0.70
NZ F:LYS524 2.4 89.0 1.0
NE2 F:HIS525 2.5 77.9 1.0
OE2 F:GLU489 2.6 83.2 1.0
CE1 F:HIS525 3.1 78.3 1.0
CB F:LYS524 3.4 83.8 1.0
CD2 F:HIS525 3.4 78.0 1.0
CD F:GLU489 3.7 82.7 1.0
CE F:LYS524 3.7 89.4 1.0
CG F:LYS524 3.8 87.0 1.0
ND1 F:HIS525 4.1 78.4 1.0
OE1 F:GLU489 4.1 85.1 1.0
CG F:HIS525 4.3 78.4 1.0
CD F:LYS524 4.4 89.2 1.0
CA F:LYS524 4.7 81.7 1.0
C F:LYS524 4.9 81.4 1.0
CG F:GLU489 4.9 80.7 1.0

Reference:

B.A.Webb, F.Forouhar, F.-E.Szu, J.Seetharaman, L.Tong, D.L.Barber. Structures of Human Phosphofructokinase-1 and Atomic Basis of Cancer-Associated Mutations To Be Published.
Page generated: Sun Dec 13 10:46:31 2020

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