Cobalt in PDB 5e8g: Crystal Structure of the Dna Binding Domain of Human Transcription Factor FLI1

The structure of Crystal Structure of the Dna Binding Domain of Human Transcription Factor FLI1, PDB code: 5e8g was solved by C.Hou, O.V.Tsodikov, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 2.70
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	140.551, 140.551, 85.140, 90.00, 90.00, 120.00
R / Rfree (%)	19.6 / 24.8

The binding sites of Cobalt atom in the Crystal Structure of the Dna Binding Domain of Human Transcription Factor FLI1 (pdb code 5e8g). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 4 binding sites of Cobalt where determined in the Crystal Structure of the Dna Binding Domain of Human Transcription Factor FLI1, PDB code: 5e8g:
Jump to Cobalt binding site number: 1; 2; 3; 4;

Cobalt binding site 1 out of 4 in the Crystal Structure of the Dna Binding Domain of Human Transcription Factor FLI1


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of the Dna Binding Domain of Human Transcription Factor FLI1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co401 b:57.6 occ:1.00 O A:HOH504 1.7 30.0 1.0 OD2 A:ASP361 1.8 50.7 1.0 ND1 A:HIS363 1.8 60.8 1.0 O A:HOH501 2.0 30.0 1.0 O A:HOH503 2.3 30.0 1.0 CG A:ASP361 2.4 46.6 1.0 OD1 A:ASP361 2.5 47.6 1.0 CE1 A:HIS363 2.7 55.0 1.0 CG A:HIS363 3.0 53.2 1.0 CB A:HIS363 3.5 53.7 1.0 NE2 A:HIS363 3.9 50.1 1.0 CB A:ASP361 3.9 46.4 1.0 CD2 A:HIS363 4.0 50.4 1.0 N A:HIS363 4.2 50.0 1.0 CA A:HIS363 4.5 52.6 1.0 CA A:ASP361 4.8 46.7 1.0 N A:PHE362 4.9 46.8 1.0

Cobalt binding site 2 out of 4 in the Crystal Structure of the Dna Binding Domain of Human Transcription Factor FLI1


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Crystal Structure of the Dna Binding Domain of Human Transcription Factor FLI1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Co401 b:58.5 occ:1.00 OD2 B:ASP361 1.8 52.4 1.0 O B:HOH501 1.8 30.0 1.0 ND1 B:HIS363 1.9 55.6 1.0 O B:HOH502 2.2 30.0 1.0 OD1 B:ASP361 2.4 45.4 1.0 CG B:ASP361 2.4 47.9 1.0 CE1 B:HIS363 2.7 50.8 1.0 CG B:HIS363 3.0 49.9 1.0 CB B:HIS363 3.5 52.4 1.0 NE2 B:HIS363 3.9 47.4 1.0 CB B:ASP361 3.9 44.8 1.0 CD2 B:HIS363 4.0 46.7 1.0 N B:HIS363 4.2 52.0 1.0 CA B:HIS363 4.5 53.4 1.0 CA B:ASP361 4.8 45.8 1.0 N B:PHE362 4.8 46.7 1.0

Cobalt binding site 3 out of 4 in the Crystal Structure of the Dna Binding Domain of Human Transcription Factor FLI1


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 3 of Crystal Structure of the Dna Binding Domain of Human Transcription Factor FLI1 within 5.0Å range: probe atom residue distance (Å) B Occ C:Co401 b:58.1 occ:1.00 OD2 C:ASP361 1.8 55.7 1.0 O C:HOH501 1.8 30.0 1.0 ND1 C:HIS363 1.8 54.9 1.0 O C:HOH503 2.1 30.0 1.0 CG C:ASP361 2.4 50.4 1.0 OD1 C:ASP361 2.5 52.6 1.0 CE1 C:HIS363 2.6 48.9 1.0 CG C:HIS363 3.1 49.6 1.0 CB C:HIS363 3.7 49.9 1.0 NE2 C:HIS363 3.8 45.0 1.0 CB C:ASP361 3.9 47.9 1.0 CD2 C:HIS363 4.0 46.0 1.0 N C:HIS363 4.2 49.3 1.0 CA C:HIS363 4.6 52.4 1.0 CA C:ASP361 4.8 46.0 1.0 N C:PHE362 5.0 45.8 1.0

Cobalt binding site 4 out of 4 in the Crystal Structure of the Dna Binding Domain of Human Transcription Factor FLI1


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 4 of Crystal Structure of the Dna Binding Domain of Human Transcription Factor FLI1 within 5.0Å range: probe atom residue distance (Å) B Occ D:Co401 b:56.1 occ:1.00 OD2 D:ASP361 1.8 49.9 1.0 ND1 D:HIS363 1.9 56.8 1.0 O D:HOH503 2.1 30.0 1.0 O D:HOH502 2.2 30.0 1.0 OD1 D:ASP361 2.4 48.3 1.0 CG D:ASP361 2.4 46.5 1.0 CE1 D:HIS363 2.6 53.9 1.0 CG D:HIS363 3.1 51.6 1.0 CB D:HIS363 3.7 53.1 1.0 NE2 D:HIS363 3.8 46.5 1.0 CB D:ASP361 4.0 47.3 1.0 CD2 D:HIS363 4.0 48.6 1.0 N D:HIS363 4.3 54.1 1.0 CA D:HIS363 4.7 54.0 1.0 CA D:ASP361 4.8 49.0 1.0 N D:PHE362 5.0 50.4 1.0

C.Hou, O.V.Tsodikov. Structural Basis For Dimerization and Dna Binding of Transcription Factor FLI1. Biochemistry V. 54 7365 2015.
ISSN: ISSN 0006-2960
PubMed: 26618620
DOI: 10.1021/ACS.BIOCHEM.5B01121