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Cobalt in PDB 5hpe: Phosphatase Domain of PP5 Bound to A Phosphomimetic CDC37 Substrate Peptide

Enzymatic activity of Phosphatase Domain of PP5 Bound to A Phosphomimetic CDC37 Substrate Peptide

All present enzymatic activity of Phosphatase Domain of PP5 Bound to A Phosphomimetic CDC37 Substrate Peptide:
3.1.3.16;

Protein crystallography data

The structure of Phosphatase Domain of PP5 Bound to A Phosphomimetic CDC37 Substrate Peptide, PDB code: 5hpe was solved by J.Oberoi, L.Mariotti, C.Vaughan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.39 / 2.27
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 42.314, 65.164, 132.117, 90.00, 90.00, 90.00
R / Rfree (%) 16.8 / 23.6

Other elements in 5hpe:

The structure of Phosphatase Domain of PP5 Bound to A Phosphomimetic CDC37 Substrate Peptide also contains other interesting chemical elements:

Manganese (Mn) 2 atoms

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Phosphatase Domain of PP5 Bound to A Phosphomimetic CDC37 Substrate Peptide (pdb code 5hpe). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Phosphatase Domain of PP5 Bound to A Phosphomimetic CDC37 Substrate Peptide, PDB code: 5hpe:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in 5hpe

Go back to Cobalt Binding Sites List in 5hpe
Cobalt binding site 1 out of 2 in the Phosphatase Domain of PP5 Bound to A Phosphomimetic CDC37 Substrate Peptide


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Phosphatase Domain of PP5 Bound to A Phosphomimetic CDC37 Substrate Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co1103

b:21.1
occ:1.00
CO A:NCO1103 0.0 21.1 1.0
N5 A:NCO1103 2.0 20.1 1.0
N3 A:NCO1103 2.0 14.0 1.0
N6 A:NCO1103 2.0 16.0 1.0
N4 A:NCO1103 2.0 22.1 1.0
N1 A:NCO1103 2.0 17.7 1.0
N2 A:NCO1103 2.0 17.5 1.0
O A:HOH1235 3.8 18.4 1.0
O A:ASN372 4.1 14.3 1.0
O A:HOH1303 4.6 18.6 1.0
ND2 A:ASN372 5.0 17.3 1.0
OE1 A:GLU336 5.0 18.5 1.0

Cobalt binding site 2 out of 2 in 5hpe

Go back to Cobalt Binding Sites List in 5hpe
Cobalt binding site 2 out of 2 in the Phosphatase Domain of PP5 Bound to A Phosphomimetic CDC37 Substrate Peptide


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Phosphatase Domain of PP5 Bound to A Phosphomimetic CDC37 Substrate Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co1104

b:35.1
occ:1.00
CO A:NCO1104 0.0 35.1 1.0
N5 A:NCO1104 1.9 39.2 1.0
N1 A:NCO1104 2.0 43.9 1.0
N2 A:NCO1104 2.0 39.3 1.0
N3 A:NCO1104 2.0 34.9 1.0
N6 A:NCO1104 2.0 47.6 1.0
N4 A:NCO1104 2.0 39.4 1.0
O A:ALA321 4.0 22.8 1.0
O A:TYR323 4.2 26.4 1.0
O A:LYS320 4.8 22.7 1.0

Reference:

J.Oberoi, D.M.Dunn, M.R.Woodford, L.Mariotti, J.Schulman, D.Bourboulia, M.Mollapour, C.K.Vaughan. Structural and Functional Basis of Protein Phosphatase 5 Substrate Specificity. Proc.Natl.Acad.Sci.Usa V. 113 9009 2016.
ISSN: ESSN 1091-6490
PubMed: 27466404
DOI: 10.1073/PNAS.1603059113
Page generated: Sun Dec 13 10:47:29 2020

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