Cobalt in PDB 5tvw: Crystal Structure of Mitochondrial HSP90 (TRAP1) with Atp in Absence of Mg, Hemi-Hydrolyzed

The structure of Crystal Structure of Mitochondrial HSP90 (TRAP1) with Atp in Absence of Mg, Hemi-Hydrolyzed, PDB code: 5tvw was solved by D.Elnatan, M.Betegon, D.A.Agard, Northeast Structural Genomicsconsortium (Nesg), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.89 / 2.50
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	178.490, 97.181, 125.904, 90.00, 134.64, 90.00
R / Rfree (%)	19 / 23.8

The binding sites of Cobalt atom in the Crystal Structure of Mitochondrial HSP90 (TRAP1) with Atp in Absence of Mg, Hemi-Hydrolyzed (pdb code 5tvw). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 4 binding sites of Cobalt where determined in the Crystal Structure of Mitochondrial HSP90 (TRAP1) with Atp in Absence of Mg, Hemi-Hydrolyzed, PDB code: 5tvw:
Jump to Cobalt binding site number: 1; 2; 3; 4;

Cobalt binding site 1 out of 4 in the Crystal Structure of Mitochondrial HSP90 (TRAP1) with Atp in Absence of Mg, Hemi-Hydrolyzed


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of Mitochondrial HSP90 (TRAP1) with Atp in Absence of Mg, Hemi-Hydrolyzed within 5.0Å range: probe atom residue distance (Å) B Occ A:Co802 b:0.9 occ:1.00 OD2 A:ASP92 2.1 0.7 1.0 OD1 A:ASP92 2.1 0.2 1.0 CG A:ASP92 2.2 0.2 1.0 CB A:ASP92 3.6 0.8 1.0 O A:ASP92 4.6 87.9 1.0 CA A:ASP92 4.6 93.5 1.0 C A:ASP92 4.7 86.4 1.0 O A:GLU94 4.9 96.9 1.0

Cobalt binding site 2 out of 4 in the Crystal Structure of Mitochondrial HSP90 (TRAP1) with Atp in Absence of Mg, Hemi-Hydrolyzed


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Crystal Structure of Mitochondrial HSP90 (TRAP1) with Atp in Absence of Mg, Hemi-Hydrolyzed within 5.0Å range: probe atom residue distance (Å) B Occ A:Co803 b:0.5 occ:1.00 OD1 A:ASN204 2.1 75.8 1.0 ND2 A:ASN204 2.2 86.3 1.0 O A:HOH972 2.2 61.0 1.0 CG A:ASN204 2.4 73.9 1.0 O A:HOH926 2.9 31.0 1.0 CB A:ASN204 4.0 69.6 1.0 CA A:ASN204 4.7 66.7 1.0 O A:LEU202 4.8 50.7 1.0 N A:ASN204 4.9 62.6 1.0 O A:ASP200 5.0 49.7 1.0

Cobalt binding site 3 out of 4 in the Crystal Structure of Mitochondrial HSP90 (TRAP1) with Atp in Absence of Mg, Hemi-Hydrolyzed


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 3 of Crystal Structure of Mitochondrial HSP90 (TRAP1) with Atp in Absence of Mg, Hemi-Hydrolyzed within 5.0Å range: probe atom residue distance (Å) B Occ B:Co801 b:0.1 occ:1.00 O B:MET505 3.7 54.7 1.0 O B:SER503 4.0 54.5 1.0 C B:MET505 4.9 68.4 1.0 C B:SER503 4.9 60.6 1.0

Cobalt binding site 4 out of 4 in the Crystal Structure of Mitochondrial HSP90 (TRAP1) with Atp in Absence of Mg, Hemi-Hydrolyzed


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 4 of Crystal Structure of Mitochondrial HSP90 (TRAP1) with Atp in Absence of Mg, Hemi-Hydrolyzed within 5.0Å range: probe atom residue distance (Å) B Occ B:Co802 b:0.2 occ:1.00 OD1 B:ASP92 2.1 0.6 1.0 OD2 B:ASP92 2.1 0.8 1.0 CG B:ASP92 2.3 0.0 1.0 CB B:ASP92 3.9 87.1 1.0 O B:GLU94 4.5 62.4 1.0 CA B:ASP92 4.7 82.9 1.0 C B:ASP92 5.0 82.9 1.0

D.Elnatan, M.Betegon, Y.Liu, T.Ramelot, M.A.Kennedy, D.A.Agard. Symmetry Broken and Rebroken During the Atp Hydrolysis Cycle of the Mitochondrial HSP90 TRAP1. Elife V. 6 2017.
ISSN: ESSN 2050-084X
PubMed: 28742020
DOI: 10.7554/ELIFE.25235