Cobalt in PDB 5vr4: Rna Octamer Containing 2'-F-4'-Ome U.

The structure of Rna Octamer Containing 2'-F-4'-Ome U., PDB code: 5vr4 was solved by J.M.Harp, M.Egli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.48 / 1.50
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	44.387, 44.387, 85.921, 90.00, 90.00, 90.00
R / Rfree (%)	18.6 / 24.3

The structure of Rna Octamer Containing 2'-F-4'-Ome U. also contains other interesting chemical elements:

Fluorine

(F)

4 atoms

The binding sites of Cobalt atom in the Rna Octamer Containing 2'-F-4'-Ome U. (pdb code 5vr4). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the Rna Octamer Containing 2'-F-4'-Ome U., PDB code: 5vr4:

Cobalt binding site 1 out of 1 in the Rna Octamer Containing 2'-F-4'-Ome U.


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Rna Octamer Containing 2'-F-4'-Ome U. within 5.0Å range: probe atom residue distance (Å) B Occ C:Co201 b:40.1 occ:0.57 CO C:CON201 0.0 40.1 0.6 N4 C:CON201 2.0 39.7 1.0 N1 C:CON201 2.0 39.9 1.0 OP2 C:A103 4.0 24.5 1.0 OP2 C:G102 4.1 30.7 1.0 O C:HOH314 4.2 38.2 1.0 N7 C:A103 4.5 19.0 1.0 O C:HOH305 4.6 42.2 1.0 H8 C:A103 4.9 23.5 1.0 O D:HOH327 4.9 35.3 1.0 H62 C:A103 5.0 24.4 1.0

E.Malek-Adamian, D.C.Guenther, S.Matsuda, S.Martinez-Montero, I.Zlatev, J.Harp, M.Burai Patrascu, D.J.Foster, J.Fakhoury, L.Perkins, N.Moitessier, R.M.Manoharan, N.Taneja, A.Bisbe, K.Charisse, M.Maier, K.G.Rajeev, M.Egli, M.Manoharan, M.J.Damha. 4'-C-Methoxy-2'-Deoxy-2'-Fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient Rnai-Mediated Gene Silencing. J. Am. Chem. Soc. V. 139 14542 2017.
ISSN: ESSN 1520-5126
PubMed: 28937776
DOI: 10.1021/JACS.7B07582