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Cobalt in PDB 6aod: Fxia Antibody Complex

Enzymatic activity of Fxia Antibody Complex

All present enzymatic activity of Fxia Antibody Complex:
3.4.21.27;

Protein crystallography data

The structure of Fxia Antibody Complex, PDB code: 6aod was solved by M.Lolicato, D.L.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 107.90 / 1.80
Space group I 4 2 2
Cell size a, b, c (Å), α, β, γ (°) 136.127, 136.127, 175.956, 90.00, 90.00, 90.00
R / Rfree (%) 18.2 / 20.7

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Fxia Antibody Complex (pdb code 6aod). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 3 binding sites of Cobalt where determined in the Fxia Antibody Complex, PDB code: 6aod:
Jump to Cobalt binding site number: 1; 2; 3;

Cobalt binding site 1 out of 3 in 6aod

Go back to Cobalt Binding Sites List in 6aod
Cobalt binding site 1 out of 3 in the Fxia Antibody Complex


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Fxia Antibody Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Co301

b:94.6
occ:0.46
CE B:LYS205 3.2 67.5 1.0
ND2 B:ASN203 3.8 43.7 1.0
NZ B:LYS205 4.1 64.1 1.0
CD B:LYS205 4.4 66.2 1.0
NZ B:LYS210 4.7 73.6 1.0
CG B:LYS205 4.7 50.9 1.0
CE B:LYS210 4.9 65.6 1.0

Cobalt binding site 2 out of 3 in 6aod

Go back to Cobalt Binding Sites List in 6aod
Cobalt binding site 2 out of 3 in the Fxia Antibody Complex


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Fxia Antibody Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Co302

b:37.5
occ:0.50
N B:GLY8 3.2 31.8 1.0
CB B:SER7 3.7 30.1 1.0
CA B:SER7 3.8 25.8 1.0
O B:HOH538 3.9 57.9 1.0
C B:SER7 4.0 30.0 1.0
CA B:GLY8 4.1 30.4 1.0
O B:HOH449 4.8 54.2 1.0
O B:HOH468 4.8 51.1 1.0
OG B:SER7 5.0 28.1 1.0

Cobalt binding site 3 out of 3 in 6aod

Go back to Cobalt Binding Sites List in 6aod
Cobalt binding site 3 out of 3 in the Fxia Antibody Complex


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 3 of Fxia Antibody Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Co701

b:96.2
occ:1.00
OH C:TYR474 3.1 40.0 1.0
O C:HOH913 3.7 45.5 1.0
CE2 C:TYR474 3.9 37.2 1.0
CZ C:TYR474 4.0 41.3 1.0
N C:ASN405 4.1 33.2 1.0
CA C:GLY404 4.4 29.1 1.0
O C:HOH914 4.5 53.3 1.0
CB C:ASN405 4.6 40.7 1.0
CG C:ASN405 4.6 46.0 1.0
ND2 C:ASN405 4.6 50.8 1.0
C C:GLY404 4.7 33.8 1.0
CA C:ASN405 4.9 33.7 1.0

Reference:

L.K.Ely, M.Lolicato, T.David, K.Lowe, Y.C.Kim, D.Samuel, P.Bessette, J.L.Garcia, T.Mikita, D.L.Minor, S.R.Coughlin. Structural Basis For Activity and Specificity of An Anticoagulant Anti-Fxia Monoclonal Antibody and A Reversal Agent. Structure V. 26 187 2018.
ISSN: ISSN 1878-4186
PubMed: 29336885
DOI: 10.1016/J.STR.2017.12.010
Page generated: Sun Dec 13 10:49:35 2020

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