Cobalt in PDB 6aod: Fxia Antibody Complex

All present enzymatic activity of Fxia Antibody Complex:
3.4.21.27;

The structure of Fxia Antibody Complex, PDB code: 6aod was solved by M.Lolicato, D.L.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	107.90 / 1.80
Space group	I 4 2 2
Cell size a, b, c (Å), α, β, γ (°)	136.127, 136.127, 175.956, 90.00, 90.00, 90.00
R / Rfree (%)	18.2 / 20.7

The binding sites of Cobalt atom in the Fxia Antibody Complex (pdb code 6aod). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 3 binding sites of Cobalt where determined in the Fxia Antibody Complex, PDB code: 6aod:
Jump to Cobalt binding site number: 1; 2; 3;

Cobalt binding site 1 out of 3 in the Fxia Antibody Complex


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Fxia Antibody Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Co301 b:94.6 occ:0.46 CE B:LYS205 3.2 67.5 1.0 ND2 B:ASN203 3.8 43.7 1.0 NZ B:LYS205 4.1 64.1 1.0 CD B:LYS205 4.4 66.2 1.0 NZ B:LYS210 4.7 73.6 1.0 CG B:LYS205 4.7 50.9 1.0 CE B:LYS210 4.9 65.6 1.0

Cobalt binding site 2 out of 3 in the Fxia Antibody Complex


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Fxia Antibody Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Co302 b:37.5 occ:0.50 N B:GLY8 3.2 31.8 1.0 CB B:SER7 3.7 30.1 1.0 CA B:SER7 3.8 25.8 1.0 O B:HOH538 3.9 57.9 1.0 C B:SER7 4.0 30.0 1.0 CA B:GLY8 4.1 30.4 1.0 O B:HOH449 4.8 54.2 1.0 O B:HOH468 4.8 51.1 1.0 OG B:SER7 5.0 28.1 1.0

Cobalt binding site 3 out of 3 in the Fxia Antibody Complex


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 3 of Fxia Antibody Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Co701 b:96.2 occ:1.00 OH C:TYR474 3.1 40.0 1.0 O C:HOH913 3.7 45.5 1.0 CE2 C:TYR474 3.9 37.2 1.0 CZ C:TYR474 4.0 41.3 1.0 N C:ASN405 4.1 33.2 1.0 CA C:GLY404 4.4 29.1 1.0 O C:HOH914 4.5 53.3 1.0 CB C:ASN405 4.6 40.7 1.0 CG C:ASN405 4.6 46.0 1.0 ND2 C:ASN405 4.6 50.8 1.0 C C:GLY404 4.7 33.8 1.0 CA C:ASN405 4.9 33.7 1.0

L.K.Ely, M.Lolicato, T.David, K.Lowe, Y.C.Kim, D.Samuel, P.Bessette, J.L.Garcia, T.Mikita, D.L.Minor, S.R.Coughlin. Structural Basis For Activity and Specificity of An Anticoagulant Anti-Fxia Monoclonal Antibody and A Reversal Agent. Structure V. 26 187 2018.
ISSN: ISSN 1878-4186
PubMed: 29336885
DOI: 10.1016/J.STR.2017.12.010