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Atomistry » Cobalt » PDB 5zt7-6eg9 » 6eg9 » |
Cobalt in PDB 6eg9: IRAK4 in Complex with PonatinibEnzymatic activity of IRAK4 in Complex with Ponatinib
All present enzymatic activity of IRAK4 in Complex with Ponatinib:
2.7.11.1; Protein crystallography data
The structure of IRAK4 in Complex with Ponatinib, PDB code: 6eg9
was solved by
L.Wang,
H.Wu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6eg9:
The structure of IRAK4 in Complex with Ponatinib also contains other interesting chemical elements:
Cobalt Binding Sites:
The binding sites of Cobalt atom in the IRAK4 in Complex with Ponatinib
(pdb code 6eg9). This binding sites where shown within
5.0 Angstroms radius around Cobalt atom.
In total 4 binding sites of Cobalt where determined in the IRAK4 in Complex with Ponatinib, PDB code: 6eg9: Jump to Cobalt binding site number: 1; 2; 3; 4; Cobalt binding site 1 out of 4 in 6eg9Go back to Cobalt Binding Sites List in 6eg9
Cobalt binding site 1 out
of 4 in the IRAK4 in Complex with Ponatinib
Mono view Stereo pair view
Cobalt binding site 2 out of 4 in 6eg9Go back to Cobalt Binding Sites List in 6eg9
Cobalt binding site 2 out
of 4 in the IRAK4 in Complex with Ponatinib
Mono view Stereo pair view
Cobalt binding site 3 out of 4 in 6eg9Go back to Cobalt Binding Sites List in 6eg9
Cobalt binding site 3 out
of 4 in the IRAK4 in Complex with Ponatinib
Mono view Stereo pair view
Cobalt binding site 4 out of 4 in 6eg9Go back to Cobalt Binding Sites List in 6eg9
Cobalt binding site 4 out
of 4 in the IRAK4 in Complex with Ponatinib
Mono view Stereo pair view
Reference:
L.Wang,
R.Ferrao,
Q.Li,
J.M.Hatcher,
H.G.Choi,
S.J.Buhrlage,
N.S.Gray,
H.Wu.
Conformational Flexibility and Inhibitor Binding to Unphosphorylated Interleukin-1 Receptor-Associated Kinase 4 (IRAK4). J.Biol.Chem. V. 294 4511 2019.
Page generated: Tue Jul 30 18:34:42 2024
ISSN: ESSN 1083-351X PubMed: 30679311 DOI: 10.1074/JBC.RA118.005428 |
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