Cobalt in PDB 6i5n: Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide

The structure of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide, PDB code: 6i5n was solved by W.W.Kung, S.Ramachandran, N.Makukhin, E.Bruno, A.Ciulli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	54.04 / 1.98
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	113.177, 156.763, 57.571, 90.00, 90.00, 90.00
R / Rfree (%)	19 / 22.6

The structure of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide also contains other interesting chemical elements:

Arsenic

(As)

7 atoms

The binding sites of Cobalt atom in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide (pdb code 6i5n). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide, PDB code: 6i5n:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Co201 b:36.6 occ:1.00 O A:HOH365 1.8 32.2 1.0 O A:HOH338 2.0 28.4 1.0 NE2 A:HIS149 2.1 49.0 1.0 NE2 K:HIS4 2.3 41.3 1.0 O K:HOH108 2.3 37.0 1.0 O A:HOH383 2.4 39.0 1.0 CE1 A:HIS149 3.0 46.0 1.0 CD2 K:HIS4 3.2 38.7 1.0 CD2 A:HIS149 3.2 44.2 1.0 CE1 K:HIS4 3.3 41.7 1.0 ND1 A:HIS149 4.2 44.8 1.0 CG A:HIS149 4.3 42.5 1.0 O A:THR147 4.3 35.4 1.0 CG K:HIS4 4.3 37.1 1.0 ND1 K:HIS4 4.4 36.1 1.0 CG2 I:VLM6 4.9 33.2 1.0

Cobalt binding site 2 out of 2 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ D:Co201 b:0.6 occ:1.00 NE2 D:HIS149 2.4 85.7 1.0 CB L:SER2 2.8 77.0 1.0 NE2 L:HIS4 2.9 74.6 1.0 CD2 L:HIS4 3.3 73.3 1.0 CD2 D:HIS149 3.3 80.4 1.0 CE1 D:HIS149 3.4 86.8 1.0 CA L:SER2 4.1 79.1 1.0 CE1 L:HIS4 4.2 74.6 1.0 ND1 D:HIS149 4.5 82.2 1.0 CG D:HIS149 4.5 77.8 1.0 O1P L:PTR0 4.5 89.3 0.9 CG L:HIS4 4.6 73.0 1.0 C L:SER2 4.8 74.2 1.0

W.W.Kung, S.Ramachandran, N.Makukhin, E.Bruno, A.Ciulli. Structural Insights Into Substrate Recognition By the SOCS2 E3 Ubiquitin Ligase. Nat Commun V. 10 2534 2019.
ISSN: ESSN 2041-1723
PubMed: 31182716
DOI: 10.1038/S41467-019-10190-4