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Atomistry » Cobalt » PDB 6oxc-6vv8 » 6vv8 » |
Cobalt in PDB 6vv8: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB285Enzymatic activity of Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB285
All present enzymatic activity of Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB285:
1.5.1.3; Protein crystallography data
The structure of Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB285, PDB code: 6vv8
was solved by
J.A.Ribeiro,
S.M.Chavez-Pacheco,
M.V.B.Dias,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Cobalt Binding Sites:
The binding sites of Cobalt atom in the Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB285
(pdb code 6vv8). This binding sites where shown within
5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB285, PDB code: 6vv8: Jump to Cobalt binding site number: 1; 2; Cobalt binding site 1 out of 2 in 6vv8Go back to Cobalt Binding Sites List in 6vv8
Cobalt binding site 1 out
of 2 in the Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB285
Mono view Stereo pair view
Cobalt binding site 2 out of 2 in 6vv8Go back to Cobalt Binding Sites List in 6vv8
Cobalt binding site 2 out
of 2 in the Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB285
Mono view Stereo pair view
Reference:
J.A.Ribeiro,
A.Hammer,
G.A.Libreros-Zuniga,
S.M.Chavez-Pacheco,
P.Tyrakis,
G.S.De Oliveira,
T.Kirkman,
J.El Bakali,
S.A.Rocco,
M.L.Sforca,
R.Parise-Filho,
A.G.Coyne,
T.L.Blundell,
C.Abell,
M.V.B.Dias.
Using A Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase Frommycobacterium Tuberculosis. Acs Infect Dis. V. 6 2192 2020.
Page generated: Sun Dec 13 10:53:27 2020
ISSN: ESSN 2373-8227 PubMed: 32603583 DOI: 10.1021/ACSINFECDIS.0C00263 |
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