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Cobalt in PDB 6vv9: Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB300Enzymatic activity of Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB300
All present enzymatic activity of Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB300:
1.5.1.3; Protein crystallography data
The structure of Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB300, PDB code: 6vv9
was solved by
J.A.Ribeiro,
S.M.Chavez-Pacheco,
M.V.B.Dias,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Cobalt Binding Sites:
The binding sites of Cobalt atom in the Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB300
(pdb code 6vv9). This binding sites where shown within
5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB300, PDB code: 6vv9: Jump to Cobalt binding site number: 1; 2; Cobalt binding site 1 out of 2 in 6vv9Go back to Cobalt Binding Sites List in 6vv9
Cobalt binding site 1 out
of 2 in the Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB300
Mono view Stereo pair view
Cobalt binding site 2 out of 2 in 6vv9Go back to Cobalt Binding Sites List in 6vv9
Cobalt binding site 2 out
of 2 in the Mycobacterium Tuberculosis Dihydrofolate Reductase in Complex with JEB300
Mono view Stereo pair view
Reference:
J.A.Ribeiro,
A.Hammer,
G.A.Libreros-Zuniga,
S.M.Chavez-Pacheco,
P.Tyrakis,
G.S.De Oliveira,
T.Kirkman,
J.El Bakali,
S.A.Rocco,
M.L.Sforca,
R.Parise-Filho,
A.G.Coyne,
T.L.Blundell,
C.Abell,
M.V.B.Dias.
Using A Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase Frommycobacterium Tuberculosis. Acs Infect Dis. V. 6 2192 2020.
Page generated: Sun Dec 13 10:53:46 2020
ISSN: ESSN 2373-8227 PubMed: 32603583 DOI: 10.1021/ACSINFECDIS.0C00263 |
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