Cobalt in PDB 6wbv: Structure of Human Ferroportin Bound to Hepcidin and Cobalt in Lipid Nanodisc

The binding sites of Cobalt atom in the Structure of Human Ferroportin Bound to Hepcidin and Cobalt in Lipid Nanodisc (pdb code 6wbv). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Structure of Human Ferroportin Bound to Hepcidin and Cobalt in Lipid Nanodisc, PDB code: 6wbv:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Structure of Human Ferroportin Bound to Hepcidin and Cobalt in Lipid Nanodisc


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Structure of Human Ferroportin Bound to Hepcidin and Cobalt in Lipid Nanodisc within 5.0Å range: probe atom residue distance (Å) B Occ A:Co703 b:66.3 occ:1.00 OD2 A:ASP39 2.1 34.1 1.0 NE2 A:HIS43 2.4 37.0 1.0 OD1 A:ASP39 2.8 34.1 1.0 CG A:ASP39 2.8 34.1 1.0 CD2 A:HIS43 3.3 37.0 1.0 CE1 A:HIS43 3.5 37.0 1.0 ND2 A:ASN144 4.1 21.1 1.0 CB A:ASP39 4.2 34.1 1.0 CG A:HIS43 4.5 37.0 1.0 ND1 A:HIS43 4.6 37.0 1.0 NH2 A:ARG40 4.6 36.5 1.0 O B:HIS3 4.6 33.2 1.0 OG A:SER147 4.7 21.5 1.0 CB A:SER147 4.7 21.5 1.0

Cobalt binding site 2 out of 2 in the Structure of Human Ferroportin Bound to Hepcidin and Cobalt in Lipid Nanodisc


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Structure of Human Ferroportin Bound to Hepcidin and Cobalt in Lipid Nanodisc within 5.0Å range: probe atom residue distance (Å) B Occ A:Co704 b:59.4 occ:1.00 O A:HOH806 1.8 43.8 1.0 O B:THR25 1.8 53.4 1.0 NE2 A:HIS507 2.1 35.3 1.0 SG A:CYS326 2.2 49.1 1.0 C B:THR25 2.7 53.4 1.0 CE1 A:HIS507 2.9 35.3 1.0 OXT B:THR25 3.0 53.4 1.0 CB A:CYS326 3.2 49.1 1.0 CD2 A:HIS507 3.3 35.3 1.0 CA A:CYS326 3.5 49.1 1.0 O A:HOH804 4.0 40.9 1.0 ND1 A:HIS507 4.1 35.3 1.0 CA B:THR25 4.2 53.4 1.0 CG A:HIS507 4.3 35.3 1.0 O A:ASP325 4.3 46.9 1.0 CG2 A:VAL511 4.5 44.5 1.0 N A:CYS326 4.5 49.1 1.0 C A:CYS326 4.6 49.1 1.0 N A:ILE327 4.6 50.3 1.0 CB B:THR25 4.7 53.4 1.0 C A:ASP325 4.8 46.9 1.0 CB A:VAL511 5.0 44.5 1.0 CG1 A:VAL511 5.0 44.5 1.0

C.B.Billesbolle, C.M.Azumaya, R.C.Kretsch, A.S.Powers, S.Gonen, S.Schneider, T.Arvedson, R.O.Dror, Y.Cheng, A.Manglik. Structure of Hepcidin-Bound Ferroportin Reveals Iron Homeostatic Mechanisms. Nature V. 586 807 2020.
ISSN: ESSN 1476-4687
PubMed: 32814342
DOI: 10.1038/S41586-020-2668-Z