Cobalt in PDB 7s0w: Crystal Structure of the T337M Variant of Human Pgm-1

All present enzymatic activity of Crystal Structure of the T337M Variant of Human Pgm-1:
5.4.2.2;

The structure of Crystal Structure of the T337M Variant of Human Pgm-1, PDB code: 7s0w was solved by K.M.Stiers, L.J.Beamer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.57 / 2.50
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	171.693, 171.693, 99.203, 90, 90, 90
R / Rfree (%)	21.5 / 27

The binding sites of Cobalt atom in the Crystal Structure of the T337M Variant of Human Pgm-1 (pdb code 7s0w). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Crystal Structure of the T337M Variant of Human Pgm-1, PDB code: 7s0w:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Crystal Structure of the T337M Variant of Human Pgm-1


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of the T337M Variant of Human Pgm-1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co601 b:35.6 occ:0.67 OD1 A:ASP292 1.9 62.5 1.0 O A:HOH707 1.9 33.8 1.0 OD2 A:ASP288 1.9 59.9 1.0 OG A:SER117 2.0 62.8 1.0 O A:HOH716 2.0 35.0 1.0 OD1 A:ASP290 2.0 55.9 1.0 CG A:ASP292 2.8 53.8 1.0 CG A:ASP290 2.9 50.9 1.0 OD2 A:ASP290 3.0 51.9 1.0 CG A:ASP288 3.0 56.9 1.0 OD2 A:ASP292 3.0 52.8 1.0 CB A:SER117 3.2 59.1 1.0 OD1 A:ASP288 3.5 58.4 1.0 CA A:SER117 3.8 58.4 1.0 CD A:ARG293 4.0 48.7 1.0 CB A:ASP292 4.2 44.1 1.0 O1 A:SO4604 4.2 117.6 0.9 N A:ASP292 4.3 43.4 1.0 CB A:ASP288 4.3 53.4 1.0 CB A:ASP290 4.3 43.7 1.0 C A:SER117 4.4 58.6 1.0 N A:ARG293 4.5 41.0 1.0 N A:HIS118 4.5 54.5 1.0 ND1 A:HIS118 4.6 70.9 1.0 CA A:ASP292 4.6 41.4 1.0 N A:ASP290 4.6 55.7 1.0 CG A:ARG293 4.7 58.8 1.0 O2 A:SO4604 4.8 114.2 0.9 C A:ASP292 4.8 43.0 1.0 CA A:ASP290 4.8 50.8 1.0 N A:GLY291 4.9 45.6 1.0 NE A:ARG293 4.9 52.7 1.0 CB A:ARG293 4.9 47.8 1.0 C A:ASP290 4.9 50.7 1.0

Cobalt binding site 2 out of 2 in the Crystal Structure of the T337M Variant of Human Pgm-1


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Crystal Structure of the T337M Variant of Human Pgm-1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Co601 b:55.0 occ:0.86 OD2 B:ASP288 1.9 96.9 1.0 OD1 B:ASP292 2.1 85.4 1.0 OG B:SER117 2.2 97.3 1.0 OD1 B:ASP290 2.2 69.8 1.0 CG B:ASP288 2.6 91.6 1.0 OD1 B:ASP288 2.9 99.9 1.0 CG B:ASP292 3.0 71.5 1.0 CG B:ASP290 3.0 66.8 1.0 OD2 B:ASP290 3.2 67.6 1.0 CB B:SER117 3.2 84.7 1.0 OD2 B:ASP292 3.3 69.0 1.0 CB B:ASP288 3.8 84.1 1.0 CA B:SER117 3.8 79.8 1.0 O4 B:SO4604 4.1 138.7 1.0 C B:SER117 4.3 75.7 1.0 N B:HIS118 4.3 77.6 1.0 N B:ASP292 4.4 60.5 1.0 CG B:ARG293 4.4 64.5 1.0 CB B:ASP292 4.4 65.3 1.0 CB B:ASP290 4.5 64.5 1.0 ND1 B:HIS118 4.6 86.6 1.0 CD B:ARG293 4.6 64.5 1.0 NE B:ARG293 4.6 68.3 1.0 N B:ASP290 4.7 67.0 1.0 N B:ARG293 4.7 57.2 1.0 CA B:ASP292 4.8 62.3 1.0 C B:ASP292 4.9 57.9 1.0 N B:GLY291 5.0 61.6 1.0 CA B:ASP290 5.0 64.4 1.0

K.M.Stiers, L.F.Owuocha, L.J.Beamer. Effects of the T337M and G391V Disease-Related Variants on Human Phosphoglucomutase 1: Structural Disruptions Large and Small. Acta Crystallogr.,Sect.F V. 78 200 2022.
ISSN: ESSN 2053-230X
PubMed: 35506765
DOI: 10.1107/S2053230X22004174