Cobalt in PDB 8edp: Crystal Structure of A Three-Tetrad, Parallel, and K+ Stabilized Homopurine G-Quadruplex From Human Chromosome 7

The structure of Crystal Structure of A Three-Tetrad, Parallel, and K+ Stabilized Homopurine G-Quadruplex From Human Chromosome 7, PDB code: 8edp was solved by M.Ye, L.A.Yatsunyk, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.01 / 2.01
Space group	P 2 21 21
Cell size a, b, c (Å), α, β, γ (°)	30.583, 40.927, 56.018, 90, 90, 90
R / Rfree (%)	24.3 / 27.8

The structure of Crystal Structure of A Three-Tetrad, Parallel, and K+ Stabilized Homopurine G-Quadruplex From Human Chromosome 7 also contains other interesting chemical elements:

Potassium

(K)

4 atoms

The binding sites of Cobalt atom in the Crystal Structure of A Three-Tetrad, Parallel, and K+ Stabilized Homopurine G-Quadruplex From Human Chromosome 7 (pdb code 8edp). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the Crystal Structure of A Three-Tetrad, Parallel, and K+ Stabilized Homopurine G-Quadruplex From Human Chromosome 7, PDB code: 8edp:

Cobalt binding site 1 out of 1 in the Crystal Structure of A Three-Tetrad, Parallel, and K+ Stabilized Homopurine G-Quadruplex From Human Chromosome 7


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of A Three-Tetrad, Parallel, and K+ Stabilized Homopurine G-Quadruplex From Human Chromosome 7 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co101 b:178.7 occ:0.82 CO A:NCO101 0.0 178.7 0.8 N3 A:NCO101 2.0 142.5 0.8 N6 A:NCO101 2.0 150.0 0.8 N5 A:NCO101 2.0 151.6 0.8 N1 A:NCO101 2.0 149.6 0.8 N4 A:NCO101 2.0 144.1 0.8 N2 A:NCO101 2.0 142.5 0.8 OP1 A:DG21 4.1 86.5 1.0

M.Ye, E.V.Chen, S.H.Pfeil, K.N.Martin, T.Atrafi, S.Yun, Z.Martinez, L.A.Yatsunyk. Homopurine Guanine-Rich Sequences in Complex with N-Methyl Mesoporphyrin IX Form Parallel G-Quadruplex Dimers and Display A Unique Symmetry Tetrad. Bioorg.Med.Chem. V. 77 17112 2022.
ISSN: ESSN 1464-3391
PubMed: 36508994
DOI: 10.1016/J.BMC.2022.117112