Cobalt in PDB 8hcd: Crystal Structure of MTREX1-Dna Product Complex (Dnmp)

All present enzymatic activity of Crystal Structure of MTREX1-Dna Product Complex (Dnmp):
3.1.11.2;

The structure of Crystal Structure of MTREX1-Dna Product Complex (Dnmp), PDB code: 8hcd was solved by Y.Y.Hsiao, K.W.Huang, C.Y.Wu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.29 / 2.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	67.68, 81.284, 93.209, 90, 103.69, 90
R / Rfree (%)	19.5 / 24

The structure of Crystal Structure of MTREX1-Dna Product Complex (Dnmp) also contains other interesting chemical elements:

Magnesium

(Mg)

8 atoms

The binding sites of Cobalt atom in the Crystal Structure of MTREX1-Dna Product Complex (Dnmp) (pdb code 8hcd). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the Crystal Structure of MTREX1-Dna Product Complex (Dnmp), PDB code: 8hcd:

Cobalt binding site 1 out of 1 in the Crystal Structure of MTREX1-Dna Product Complex (Dnmp)


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of MTREX1-Dna Product Complex (Dnmp) within 5.0Å range: probe atom residue distance (Å) B Occ E:Co304 b:69.2 occ:1.00 H E:ALA214 2.6 35.2 1.0 HB2 E:GLN213 2.6 49.8 1.0 H E:GLN213 2.8 44.0 1.0 HB3 E:LYS211 3.1 37.5 1.0 HA E:LYS211 3.2 33.6 1.0 HD2 E:PRO212 3.3 37.8 1.0 N E:GLN213 3.3 36.7 1.0 HG2 E:GLN213 3.3 56.1 1.0 N E:ALA214 3.4 29.3 1.0 CB E:GLN213 3.4 41.5 1.0 O D:HOH573 3.4 51.2 1.0 C E:LYS211 3.5 24.8 1.0 CA E:LYS211 3.7 28.0 1.0 N E:PRO212 3.7 29.1 1.0 HG2 E:LYS211 3.8 41.9 1.0 CB E:LYS211 3.8 31.2 1.0 CA E:GLN213 3.8 37.6 1.0 HB2 E:ALA214 3.8 35.6 1.0 CG E:GLN213 3.8 46.7 1.0 HB3 E:ALA214 3.9 35.6 1.0 CD E:PRO212 3.9 31.5 1.0 O E:LYS211 3.9 23.0 1.0 HG3 E:GLN213 4.0 56.1 1.0 C E:GLN213 4.1 37.0 1.0 O E:HOH443 4.2 38.0 1.0 CB E:ALA214 4.2 29.7 1.0 HB3 E:GLN213 4.2 49.8 1.0 C E:PRO212 4.2 29.8 1.0 CG E:LYS211 4.3 35.0 1.0 HD3 E:PRO212 4.3 37.8 1.0 CA E:ALA214 4.4 27.6 1.0 HG13 E:ILE49 4.4 50.1 1.0 CA E:PRO212 4.5 29.3 1.0 HB2 E:LYS211 4.6 37.5 1.0 HA E:GLN213 4.7 45.1 1.0 HD3 E:LYS211 4.7 48.1 1.0 H E:LEU215 4.8 35.4 1.0 HA E:ALA214 5.0 33.2 1.0 HZ1 E:LYS211 5.0 51.9 1.0

Y.Y.Hsiao, K.W.Huang, C.Y.Wu. Molecular Insight Into the Specific Enzymatic Properties of TREX1 Revealing the Diverse Functions in Processing Rna and Dna/Rna Hybrids. Nucleic Acids Res. 2023.
ISSN: ESSN 1362-4962
DOI: 10.1093/NAR/GKAD910