Cobalt in PDB 2xg4: E. Coli P Pilus Chaperone-Subunit Complex Papd-Paph Bound to Pilus Biogenesis Inhibitor, Pilicide 2C

The structure of E. Coli P Pilus Chaperone-Subunit Complex Papd-Paph Bound to Pilus Biogenesis Inhibitor, Pilicide 2C, PDB code: 2xg4 was solved by H.Remaut, G.Phan, F.Buelens, E.Chorell, J.S.Pinkner, S.Edvinsson, F.Almqvist, S.J.Hultgren, G.Waksman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.40
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	104.100, 148.730, 82.639, 90.00, 90.00, 90.00
R / Rfree (%)	18.332 / 21.745

The binding sites of Cobalt atom in the E. Coli P Pilus Chaperone-Subunit Complex Papd-Paph Bound to Pilus Biogenesis Inhibitor, Pilicide 2C (pdb code 2xg4). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the E. Coli P Pilus Chaperone-Subunit Complex Papd-Paph Bound to Pilus Biogenesis Inhibitor, Pilicide 2C, PDB code: 2xg4:

Cobalt binding site 1 out of 1 in the E. Coli P Pilus Chaperone-Subunit Complex Papd-Paph Bound to Pilus Biogenesis Inhibitor, Pilicide 2C


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of E. Coli P Pilus Chaperone-Subunit Complex Papd-Paph Bound to Pilus Biogenesis Inhibitor, Pilicide 2C within 5.0Å range: probe atom residue distance (Å) B Occ B:Co1174 b:47.7 occ:0.50 NE2 B:HIS28 2.2 39.7 1.0 CE1 B:HIS28 3.1 33.4 1.0 CD2 B:HIS28 3.3 33.0 1.0 ND1 B:HIS28 4.2 37.0 1.0 O B:ALA25 4.3 50.1 1.0 CG B:HIS28 4.4 32.6 1.0

E.Chorell, J.S.Pinkner, G.Phan, S.Edvinsson, F.Buelens, H.Remaut, G.Waksman, S.J.Hultgren, F.Almqvist. Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity. J.Med.Chem. V. 53 5690 2010.
ISSN: ISSN 0022-2623
PubMed: 20586493
DOI: 10.1021/JM100470T