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Cobalt in PDB 3i8v: Crystal Structure of Human PDE4A with 4-(3-Butoxy-4-Methoxyphenyl) Methyl-2-Imidazolidone

Enzymatic activity of Crystal Structure of Human PDE4A with 4-(3-Butoxy-4-Methoxyphenyl) Methyl-2-Imidazolidone

All present enzymatic activity of Crystal Structure of Human PDE4A with 4-(3-Butoxy-4-Methoxyphenyl) Methyl-2-Imidazolidone:
3.1.4.17;

Protein crystallography data

The structure of Crystal Structure of Human PDE4A with 4-(3-Butoxy-4-Methoxyphenyl) Methyl-2-Imidazolidone, PDB code: 3i8v was solved by R.K.Y.Cheng, L.Crawley, J.Barker, M.Wood, B.Felicetti, M.Whittaker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.33 / 2.25
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 105.406, 105.406, 165.252, 90.00, 90.00, 90.00
R / Rfree (%) 18.7 / 22.2

Other elements in 3i8v:

The structure of Crystal Structure of Human PDE4A with 4-(3-Butoxy-4-Methoxyphenyl) Methyl-2-Imidazolidone also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Zinc (Zn) 2 atoms

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Crystal Structure of Human PDE4A with 4-(3-Butoxy-4-Methoxyphenyl) Methyl-2-Imidazolidone (pdb code 3i8v). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the Crystal Structure of Human PDE4A with 4-(3-Butoxy-4-Methoxyphenyl) Methyl-2-Imidazolidone, PDB code: 3i8v:

Cobalt binding site 1 out of 1 in 3i8v

Go back to Cobalt Binding Sites List in 3i8v
Cobalt binding site 1 out of 1 in the Crystal Structure of Human PDE4A with 4-(3-Butoxy-4-Methoxyphenyl) Methyl-2-Imidazolidone


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of Human PDE4A with 4-(3-Butoxy-4-Methoxyphenyl) Methyl-2-Imidazolidone within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co624

b:0.5
occ:1.00
 O A:HOH679 2.4 60.6 1.0
O B:HOH682 2.7 52.1 1.0
OD2 A:ASP368 2.8 47.5 1.0
O B:HOH683 3.3 49.0 1.0
OD1 A:ASP368 3.6 45.4 1.0
CG A:ASP368 3.6 41.0 1.0
ND1 A:HIS366 3.9 46.2 1.0
ND1 B:HIS366 4.2 42.1 1.0
O A:HOH175 4.2 46.0 1.0
N B:ALA367 4.5 34.4 1.0
CA B:HIS366 4.6 33.6 1.0
CE1 A:HIS366 4.6 47.1 1.0
O A:HOH200 4.7 44.5 1.0
O B:TYR365 4.8 31.9 1.0
O B:ASP363 4.9 30.3 1.0
CB B:HIS366 4.9 34.0 1.0
CG A:HIS366 4.9 41.3 1.0
CB A:ASP368 5.0 38.6 1.0

Reference:

R.K.Y.Cheng, L.Crawley, J.Barker, M.Wood, B.Felicetti, M.Whittaker. Crystal Structure of Human PDE4A with 4-(3-Butoxy-4-Methoxyphenyl)Methyl-2-Imidazolidone To Be Published.
Page generated: Tue Jul 30 16:11:09 2024

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