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Cobalt in PDB 4iec: CYS105 Covalent Modification By 2-Hydroxyethyl Disulfide in Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C

Enzymatic activity of CYS105 Covalent Modification By 2-Hydroxyethyl Disulfide in Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C

All present enzymatic activity of CYS105 Covalent Modification By 2-Hydroxyethyl Disulfide in Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C:
3.4.11.18;

Protein crystallography data

The structure of CYS105 Covalent Modification By 2-Hydroxyethyl Disulfide in Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C, PDB code: 4iec was solved by R.Reddi, R.Gumpena, C.Kishor, A.Addlagatta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.82 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 49.330, 48.241, 56.653, 90.00, 95.17, 90.00
R / Rfree (%) 16.6 / 23.6

Other elements in 4iec:

The structure of CYS105 Covalent Modification By 2-Hydroxyethyl Disulfide in Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C also contains other interesting chemical elements:

Potassium (K) 1 atom

Cobalt Binding Sites:

The binding sites of Cobalt atom in the CYS105 Covalent Modification By 2-Hydroxyethyl Disulfide in Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C (pdb code 4iec). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the CYS105 Covalent Modification By 2-Hydroxyethyl Disulfide in Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C, PDB code: 4iec:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in 4iec

Go back to Cobalt Binding Sites List in 4iec
Cobalt binding site 1 out of 2 in the CYS105 Covalent Modification By 2-Hydroxyethyl Disulfide in Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of CYS105 Covalent Modification By 2-Hydroxyethyl Disulfide in Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co401

b:5.0
occ:1.00
 O A:HOH534 2.0 7.2 1.0
NE2 A:HIS205 2.0 2.0 1.0
OE1 A:GLU269 2.1 3.3 1.0
OD1 A:ASP142 2.1 5.9 1.0
OE2 A:GLU238 2.2 5.5 1.0
CE1 A:HIS205 3.0 3.6 1.0
CD2 A:HIS205 3.0 3.7 1.0
CG A:ASP142 3.0 3.2 1.0
CD A:GLU269 3.0 3.2 1.0
CD A:GLU238 3.1 4.4 1.0
CO A:CO402 3.2 5.7 1.0
OE2 A:GLU269 3.3 4.6 1.0
OE1 A:GLU238 3.3 8.6 1.0
OD2 A:ASP142 3.4 2.0 1.0
OG1 A:THR236 3.6 3.1 1.0
CG2 A:THR236 3.7 5.0 1.0
CB A:THR236 4.0 4.4 1.0
ND1 A:HIS205 4.1 4.0 1.0
CG A:HIS205 4.1 4.5 1.0
O A:HOH509 4.2 13.2 1.0
CB A:ASP142 4.2 3.5 1.0
CG A:GLU269 4.3 2.6 1.0
CG A:GLU238 4.4 5.1 1.0
NE2 A:HIS212 4.7 10.0 1.0
OD2 A:ASP131 4.9 6.8 1.0
CB A:GLU238 4.9 2.7 1.0

Cobalt binding site 2 out of 2 in 4iec

Go back to Cobalt Binding Sites List in 4iec
Cobalt binding site 2 out of 2 in the CYS105 Covalent Modification By 2-Hydroxyethyl Disulfide in Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of CYS105 Covalent Modification By 2-Hydroxyethyl Disulfide in Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co402

b:5.7
occ:1.00
 O A:HOH534 2.0 7.2 1.0
OE2 A:GLU269 2.1 4.6 1.0
OD2 A:ASP142 2.1 2.0 1.0
OD1 A:ASP131 2.1 6.8 1.0
OD2 A:ASP131 2.2 6.8 1.0
O A:HOH509 2.3 13.2 1.0
CG A:ASP131 2.5 6.1 1.0
CG A:ASP142 3.0 3.2 1.0
CD A:GLU269 3.0 3.2 1.0
OD1 A:ASP142 3.1 5.9 1.0
CO A:CO401 3.2 5.0 1.0
OE1 A:GLU269 3.3 3.3 1.0
CB A:ASP131 4.0 4.1 1.0
OG1 A:THR133 4.2 7.3 1.0
OE1 A:GLU238 4.2 8.6 1.0
ND2 A:ASN144 4.3 3.4 1.0
CE A:CME105 4.4 25.3 1.0
CG A:GLU269 4.4 2.6 1.0
CB A:ASP142 4.4 3.5 1.0
N A:THR143 4.5 6.8 1.0
O A:THR143 4.5 8.1 1.0
O A:HOH512 4.6 5.4 1.0
OE2 A:GLU238 4.6 5.5 1.0
CB A:ASN144 4.7 5.3 1.0
CD A:GLU238 4.7 4.4 1.0
C A:ASP142 4.8 4.5 1.0
C A:THR143 4.8 7.1 1.0
CA A:ASP131 4.8 8.3 1.0
CB A:GLU269 4.9 2.0 1.0
N A:VAL132 4.9 7.5 0.5
CA A:ASP142 4.9 3.8 1.0
NE2 A:HIS205 5.0 2.0 1.0

Reference:

R.Reddi, R.Gumpena, C.Kishor, A.Addlagatta. CYS105 Covalent Modification By 2-Hydroxyethyl Disulfide in Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C To Be Published.
Page generated: Tue Jul 30 17:10:46 2024

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