Cobalt in PDB 4if7: Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C in Complex with Homocysteine-Methyl Disulfide

All present enzymatic activity of Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C in Complex with Homocysteine-Methyl Disulfide:
3.4.11.18;

The structure of Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C in Complex with Homocysteine-Methyl Disulfide, PDB code: 4if7 was solved by R.Reddi, R.Gumpena, C.Kishor, A.Addlagatta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.41 / 2.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	49.380, 48.216, 56.400, 90.00, 95.25, 90.00
R / Rfree (%)	20.1 / 26.6

The binding sites of Cobalt atom in the Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C in Complex with Homocysteine-Methyl Disulfide (pdb code 4if7). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C in Complex with Homocysteine-Methyl Disulfide, PDB code: 4if7:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C in Complex with Homocysteine-Methyl Disulfide


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C in Complex with Homocysteine-Methyl Disulfide within 5.0Å range: probe atom residue distance (Å) B Occ A:Co401 b:20.4 occ:1.00 OXT A:HCM403 1.9 18.2 0.7 OE1 A:GLU269 2.0 17.0 1.0 OE2 A:GLU238 2.1 18.4 1.0 NE2 A:HIS205 2.1 18.6 1.0 OD1 A:ASP142 2.2 19.2 1.0 C A:HCM403 2.7 19.8 0.7 CD A:GLU269 3.0 15.4 1.0 CD2 A:HIS205 3.1 18.9 1.0 O A:HCM403 3.1 18.8 0.7 CD A:GLU238 3.1 18.1 1.0 CE1 A:HIS205 3.2 18.2 1.0 CG A:ASP142 3.2 18.1 1.0 CO A:CO402 3.3 22.1 1.0 OE2 A:GLU269 3.4 15.2 1.0 OE1 A:GLU238 3.4 21.5 1.0 OG1 A:THR236 3.6 13.6 1.0 OD2 A:ASP142 3.7 16.4 1.0 CG2 A:THR236 3.8 16.9 1.0 CB A:THR236 4.0 16.4 1.0 CA A:HCM403 4.0 21.9 0.7 CG A:HIS205 4.2 18.8 1.0 ND1 A:HIS205 4.2 17.9 1.0 CB A:ASP142 4.3 17.6 1.0 CG A:GLU269 4.3 16.8 1.0 CG A:GLU238 4.4 18.5 1.0 O A:HOH564 4.4 29.3 1.0 N A:HCM403 4.4 20.4 0.7 O A:HOH504 4.6 27.5 1.0 CB A:GLU238 4.8 19.1 1.0 NE2 A:HIS212 4.8 22.9 1.0

Cobalt binding site 2 out of 2 in the Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C in Complex with Homocysteine-Methyl Disulfide


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C in Complex with Homocysteine-Methyl Disulfide within 5.0Å range: probe atom residue distance (Å) B Occ A:Co402 b:22.1 occ:1.00 OE2 A:GLU269 2.1 15.2 1.0 OD2 A:ASP142 2.1 16.4 1.0 OXT A:HCM403 2.1 18.2 0.7 OD1 A:ASP131 2.2 23.0 1.0 N A:HCM403 2.3 20.4 0.7 OD2 A:ASP131 2.4 19.7 1.0 CA A:HCM403 2.5 21.9 0.7 CG A:ASP131 2.6 20.6 1.0 C A:HCM403 2.7 19.8 0.7 CG A:ASP142 2.9 18.1 1.0 CD A:GLU269 3.0 15.4 1.0 OD1 A:ASP142 3.1 19.2 1.0 CO A:CO401 3.3 20.4 1.0 OE1 A:GLU269 3.3 17.0 1.0 O A:HCM403 3.9 18.8 0.7 CB A:HCM403 4.0 24.3 0.7 OG1 A:THR133 4.0 24.0 1.0 CB A:ASP131 4.1 20.7 1.0 ND2 A:ASN144 4.2 19.7 1.0 CB A:ASP142 4.4 17.6 1.0 CG A:GLU269 4.4 16.8 1.0 N A:THR143 4.5 24.4 1.0 OE1 A:GLU238 4.6 21.5 1.0 O A:HOH519 4.7 19.0 1.0 OE2 A:GLU238 4.7 18.4 1.0 O A:THR143 4.7 25.5 1.0 O A:HOH504 4.7 27.5 1.0 C A:ASP142 4.8 22.4 1.0 CB A:ASN144 4.8 20.7 1.0 O A:VAL132 4.8 18.2 1.0 C A:THR143 4.8 23.2 1.0 CA A:ASP142 4.8 18.8 1.0 CA A:ASP131 4.9 21.1 1.0 N A:VAL132 4.9 22.5 1.0 CB A:GLU269 5.0 16.8 1.0 CG A:HCM403 5.0 26.3 0.7 CD A:GLU238 5.0 18.1 1.0

R.Reddi, R.Gumpena, C.Kishor, A.Addlagatta. Mycobacterium Tuberculosis Methionine Aminopeptidase Type 1C in Complex with Homocysteine-Methyl Disulfide To Be Published.