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Cobalt in PDB 5cls: Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A

Enzymatic activity of Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A

All present enzymatic activity of Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A:
3.4.11.18;

Protein crystallography data

The structure of Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A, PDB code: 5cls was solved by R.Janowski, A.K.Miller, D.Niessing, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.82 / 1.75
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 89.620, 101.180, 100.280, 90.00, 90.00, 90.00
R / Rfree (%) 16 / 18.9

Other elements in 5cls:

The structure of Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A (pdb code 5cls). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A, PDB code: 5cls:

Cobalt binding site 1 out of 1 in 5cls

Go back to Cobalt Binding Sites List in 5cls
Cobalt binding site 1 out of 1 in the Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Structure of Human Methionine Aminopeptidase-2 Complexed with Spiroepoxytriazole Inhibitor (+)-31A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co501

b:39.6
occ:0.50
 OD1 A:ASP262 1.9 23.0 1.0
OD2 A:ASP251 2.2 21.8 1.0
OD1 A:ASP251 2.2 17.7 1.0
OE1 A:GLU459 2.4 23.1 1.0
CG A:ASP251 2.5 17.9 1.0
CG A:ASP262 2.9 22.0 1.0
OD2 A:ASP262 3.2 26.6 1.0
O A:HOH623 3.2 33.7 1.0
CD A:GLU459 3.3 20.6 1.0
OE2 A:GLU459 3.3 23.1 1.0
OE1 A:GLU364 4.0 57.1 1.0
C8 A:52T506 4.0 41.9 1.0
NE2 A:GLN457 4.0 15.4 1.0
CB A:ASP251 4.0 16.5 1.0
CZ A:PHE219 4.0 14.0 1.0
O A:HOH615 4.1 26.2 0.5
CB A:ASP262 4.3 18.7 1.0
CE1 A:PHE219 4.3 14.5 1.0
CB A:ALA264 4.4 15.0 1.0
N1 A:52T506 4.5 38.0 1.0
O1 A:52T506 4.6 36.9 1.0
N A:CYS263 4.7 15.0 1.0
C A:ASP262 4.7 17.5 1.0
CG A:GLU459 4.7 19.3 1.0
CA A:ASP262 4.7 16.5 1.0
CA A:ASP251 4.8 14.0 1.0
CE2 A:PHE219 4.9 14.9 1.0
CD A:GLU364 5.0 51.9 1.0

Reference:

M.Morgen, C.Jost, M.Malz, R.Janowski, D.Niessing, C.D.Klein, N.Gunkel, A.K.Miller. Spiroepoxytriazoles Are Fumagillin-Like Irreversible Inhibitors of METAP2 with Potent Cellular Activity. Acs Chem.Biol. V. 11 1001 2016.
ISSN: ESSN 1554-8937
PubMed: 26686773
DOI: 10.1021/ACSCHEMBIO.5B00755
Page generated: Sun Jul 13 20:18:03 2025

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